Because of the translational requirement of SPORE research, it is essential that SPORE investigators have access to and assistance with animal models for therapeutic hypothesis testing. The UCSF Brain Tumor SPORE Animal Core will address this need by utilizing serially-passaged human GBM xenografts in conducting in vivo studies using immune-deficient mice and rats. Emphasis will be placed on the use of serially-passaged xenografts since our cumulative experience with this system of tumor propagation indicates that serial in vivo passaging promotes tumor retention of key properties that are lost during cell line establishment. In additon, the Animal Core will emphasize orthotopic (intracranial) therapeutic testing because intracranial tumors established from serially propagated flank xenografts are highly invasive, and therefore present a more rigorous and clinically-relevant test of therapeutic efficacy than would be provided by the well-circumscribed subcutaneous tumors propagated in the flanks of nude mice, or by well-circumscribed intracranial tumors that are produced by injection of established cell lines. In association with this test model philosophy, the objectives of the UCSF Brain Tumor Animal Core are as follows:
Aim 1 : Propagate, analyze (histopathological and molecular), archive, and maintain up-to-date records on all GBM xenografts used in support of SPORE animal model research.
Aim 2 : Coordinate and conduct all immune deficient rodent therapeutics testing, including optical imaging and molecular analyses of intracranial xenograft specimens, in assessing tumor response to therapy.
Aim 3 : In association with the Tissue and Outcome Core, utilize xenograft resources to facilitate interpretation of results from immunohistochemical and FISH analysis of therapeutic targets and/or surrogate markers in patient tumors.
Aim 4 : Collect, process, and distribute, within and outside of UCSF, xenograft tumor tissues and tissue extracts, so as to promote intra- and inter-SPORE collaborations, and utilization of these renewable tumor resources.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Choi, Serah; Yu, Yao; Grimmer, Matthew R et al. (2018) Temozolomide-associated hypermutation in gliomas. Neuro Oncol 20:1300-1309
Jacobs, Daniel I; Liu, Yanhong; Gabrusiewicz, Konrad et al. (2018) Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients. J Neurooncol 136:33-39
Berntsson, Shala G; Merrell, Ryan T; Amirian, E Susan et al. (2018) Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study. J Neurol 265:1432-1442
Goode, Benjamin; Joseph, Nancy M; Stevers, Meredith et al. (2018) Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol 31:660-673
Hayes, Josie; Yu, Yao; Jalbert, Llewellyn E et al. (2018) Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. Neuro Oncol 20:632-641
Ostrom, Quinn T; Kinnersley, Ben; Armstrong, Georgina et al. (2018) Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age. Int J Cancer 143:2359-2366
Pekmezci, Melike; Stevers, Meredith; Phillips, Joanna J et al. (2018) Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol 135:485-488
Behr, Spencer C; Villanueva-Meyer, Javier E; Li, Yan et al. (2018) Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR. JCI Insight 3:
Taylor, Jennie W; Parikh, Mili; Phillips, Joanna J et al. (2018) Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma. J Neurooncol 140:477-483
Luks, Tracy L; McKnight, Tracy Richmond; Jalbert, Llewellyn E et al. (2018) Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas. Transl Oncol 11:941-949

Showing the most recent 10 out of 362 publications