The University of Texas M.D. Anderson Cancer Center is proposing a Specialized Program of Research Excellence (SPORE) in Leukemia. The primary goal of this Leukemia SPORE is to cultivate and facilitate innovative and significant translational research in the biologic, genetic and clinical aspects of leukemia to improve understanding, therapy, and prognosis. The multidisciplinary group of investigators in the Leukemia SPORE will accomplish this goal through effective integration of laboratory, epidemiologic and clinical investigations. The SPORE is designed with 5 research projects and 3 core resources, as well as programs for developmental research and career development. The research projects are designed to target specific areas important in leukemia. ? ? Project 1 - Epigenetics and epigenetic therapy in AML ? Project 2 - Adoptive Cellular Therapy for Myeloid Leukemia ? Project 3 - p53 Activation as Novel Therapeutic Strategy for Acute Myelogenous Leukemia ? Project 4 - Incorporating FLT3 inhibitors into AML treatment regimens ? Project 5 - Development of Sepacitabine Therapy in Leukemia's ? ? Core and other resources are: ? Core A - Administration ? Core B - Pathology and Tissue Core ? Core C- Biostatistics and Data Management ? ? Development Research Program and Career Development Program. ? Through this leukemia SPORE, our research team will make a significant impact on leukemia prognosis. ? ? Lay Abstract: This leukemia SPORE integrates clinical and basic investigations to introduce new therapies in leukemia that are aimed at increasing the cure rate in this disease. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
2P50CA100632-06
Application #
7431000
Study Section
Special Emphasis Panel (ZCA1-RPRB-M (J1))
Program Officer
Nothwehr, Steven F
Project Start
2003-08-05
Project End
2013-04-30
Budget Start
2008-09-01
Budget End
2009-04-30
Support Year
6
Fiscal Year
2008
Total Cost
$2,300,000
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
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