The goal of the Mayo SPORE In Brain Cancer Developmental Research Program (DRP) is to support innovative and scientifically sound projects that investigate questions pertaining to some aspect of translational research in malignant gliomas and other primary brain tumors. The DRP will provide two one year awards of $50,000 each. Dr. Robert B. Jenkins, overall Co-PI of the SPORE, will direct the program. The premise of this program is that support of developmental research projects will result in the generation of new hypotheses that will be tested within SPORE-sponsored projects or through peer-reviewed external grant support. The long-term goal of the program Is to translate the findings generated by developmental grants into effective interventions in patients with, and persons at risk for, primary brain tumors. An equally important goal is the attraction of new Investigators and their expertise to the challenges of brain cancer research. The DRP objectives are to: (1) stimulate Innovative and translationally-relevant laboratory, population science and clinical studies in primary brain tumors;(2) foster extensive collaboration between basic science, population science and clinical disciplines to advance brain tumor translational research, and (3) encourage investigators in related fields to apply their expertise to translational research in brain tumors. The Program will be administered through the Administrative Core of the SPORE. One-page outlines of two potential research projects are included to demonstrate the depth and breadth of ongoing research that can be eligible for funding through the SPORE Developmental Research Program. These two potential projects represent under-developed areas within glioma research.

Public Health Relevance

The Mayo SPORE in Brain Cancer Developmental Research Program was established to fund early phase research that take maximum advantage of SPORE resources to generate feasibility data for projects that have the highest translational potential. In so doing the DRP will develop scientists who will advance and significantly impact the nation's brain tumor agenda.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA108961-08
Application #
8567085
Study Section
Special Emphasis Panel (ZCA1-GRB-I)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
8
Fiscal Year
2013
Total Cost
$86,887
Indirect Cost
$32,308
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Jung, Mi-Yeon; Kang, Jeong-Han; Hernandez, Danielle M et al. (2018) Fatty acid synthase is required for profibrotic TGF-? signaling. FASEB J 32:3803-3815
Msaouel, Pavlos; Opyrchal, Mateusz; Dispenzieri, Angela et al. (2018) Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects. Curr Cancer Drug Targets 18:177-187
Zhou, Dan; Alver, Bonnie M; Li, Shuang et al. (2018) Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues. Genome Biol 19:43
Vaubel, Rachael A; Caron, Alissa A; Yamada, Seiji et al. (2018) Recurrent copy number alterations in low-grade and anaplastic pleomorphic xanthoastrocytoma with and without BRAF V600E mutation. Brain Pathol 28:172-182
Chen, Xiaoyue; Zhang, Minjie; Gan, Haiyun et al. (2018) A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma. Nat Commun 9:2949
Nowsheen, Somaira; Aziz, Khaled; Aziz, Asef et al. (2018) L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nat Cell Biol 20:455-464
Chen, Jee-Wei E; Pedron, Sara; Shyu, Peter et al. (2018) Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior. Front Mater 5:
Youland, Ryan S; Pafundi, Deanna H; Brinkmann, Debra H et al. (2018) Prospective trial evaluating the sensitivity and specificity of 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (18F-DOPA) PET and MRI in patients with recurrent gliomas. J Neurooncol 137:583-591
Stathias, Vasileios; Jermakowicz, Anna M; Maloof, Marie E et al. (2018) Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nat Commun 9:5315
Huff, Amanda L; Wongthida, Phonphimon; Kottke, Timothy et al. (2018) APOBEC3 Mediates Resistance to Oncolytic Viral Therapy. Mol Ther Oncolytics 11:1-13

Showing the most recent 10 out of 254 publications