Project 3 Stroke is the leading cause of disability in the United States. Speech and language deficits (aphasia) following stroke are common. Yet, some individuals with aphasia experience rapid spontaneous recovery while others are left with persistent deficits. Likewise, rehabilitation appears to help some individuals but not others. Beyond the severity of initial impairments, we have no proven way to predict the extent of recovery one can expect. We suggest that better prognostic measures could help tailor individual treatment. The objective of this proposal is to determine whether the combination of neuroimaging, acute behavior and other biomarkers can improve our ability to map and predict recovery from stroke. First, we will use a new technique to map the anatomy of apraxia of speech, aphasia, a common symptom of left hemisphere injury. Second, we will see if we can predict the effectiveness of treatment provided to patients with chronic aphasia. Third, we will see whether these methods can also predict recovery in acute/subacute patients who receive either rehabilitation or a combined rehabilitation and brain stimulation therapy. Finally, we will explore if this computer-aided prognosis can be fully automated, providing an objective tool to help predict recovery from stroke.
Project 3 Speech and language deficits are common following stroke. We suggest that the combination of behavioral testing, neuroimaging measures and other biomarkers may provide accurate prediction for recovery and the efficacy of treatment.
| Hillis, Argye E; Beh, Yuan Ye; Sebastian, Rajani et al. (2018) Predicting recovery in acute poststroke aphasia. Ann Neurol 83:612-622 |
| Ficek, Bronte N; Wang, Zeyi; Zhao, Yi et al. (2018) The effect of tDCS on functional connectivity in primary progressive aphasia. Neuroimage Clin 19:703-715 |
| Henry, Maya L; Hubbard, H Isabel; Grasso, Stephanie M et al. (2018) Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain 141:1799-1814 |
| Tippett, Donna C; Godin, Brittany R; Oishi, Kumiko et al. (2018) Impaired Recognition of Emotional Faces after Stroke Involving Right Amygdala or Insula. Semin Speech Lang 39:87-100 |
| Karnath, Hans-Otto; Sperber, Christoph; Rorden, Christopher (2018) Mapping human brain lesions and their functional consequences. Neuroimage 165:180-189 |
| Rorden, Christopher; Li, Dongyun; Karnath, Hans-Otto (2018) Biased temporal order judgments in chronic neglect influenced by trunk position. Cortex 99:273-280 |
| Peters, Denise M; Fridriksson, Julius; Stewart, Jill C et al. (2018) Cortical disconnection of the ipsilesional primary motor cortex is associated with gait speed and upper extremity motor impairment in chronic left hemispheric stroke. Hum Brain Mapp 39:120-132 |
| Tippett, Donna C (2018) Acute Care Management of Stroke. Semin Speech Lang 39:1-2 |
| Sebastian, Rajani; Breining, Bonnie L (2018) Contributions of Neuroimaging to Understanding Language Deficits in Acute Stroke. Semin Speech Lang 39:66-78 |
| Shahid, Hinna; Sebastian, Rajani; Tippett, Donna C et al. (2018) Regional Brain Dysfunction Associated with Semantic Errors in Comprehension. Semin Speech Lang 39:79-86 |
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