Abstract

The mission of the Center is to enhance the knowledge and understanding of the etiology pathogenesis and prevention of dental caries and to encourage implementation of preventive methods. All four strategy areas are addressed as follows: 1. Combating Microbial Agents: a. Implantable Ammonia Producing Streptococci, b. Immunochemical Studies of Actinomyces viscosus Polysaccharides, c. Adherence of Oral Bacteria to Human Root Surfaces, d. Genetics of Streptococcus mutans. 2. Increasing Resistance of Tooth and Host: a. Salivary Pellicle and Dental Caries. 3. Modifying Diet: a. Effects of Food Preservatives in Dental Caries, b. Animal Model for Root Surface Caries and Hyposalivation. 4. Improving Delivery and Acceptance: a. Hyposalivation: 1. Hyposalivation Drug Use and Caries in the Elderly, 2. Radiation induced Xerostomia and Caries Parameters, b. Identification of Caries Susceptible Subjects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE007003-05
Application #
3105621
Study Section
(SRC)
Project Start
1984-09-01
Project End
1989-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Miguel, J C; Bowen, W H; Pearson, S K (1997) Effects of frequency of exposure to iron-sucrose on the incidence of dental caries in desalivated rats. Caries Res 31:238-43
Vacca-Smith, A M; Venkitaraman, A R; Schilling, K M et al. (1996) Characterization of glucosyltransferase of human saliva adsorbed onto hydroxyapatite surfaces. Caries Res 30:354-60
Venkitaraman, A R; Vacca-Smith, A M; Kopec, L K et al. (1995) Characterization of glucosyltransferaseB, GtfC, and GtfD in solution and on the surface of hydroxyapatite. J Dent Res 74:1695-701
Van Wuyckhuyse, B C; Perinpanayagam, H E; Bevacqua, D et al. (1995) Association of free arginine and lysine concentrations in human parotid saliva with caries experience. J Dent Res 74:686-90
Perinpanayagam, H E; Van Wuyckhuyse, B C; Ji, Z S et al. (1995) Characterization of low-molecular-weight peptides in human parotid saliva. J Dent Res 74:345-50
Zhang, G H; Melvin, J E (1994) Nicotine increases [Ca2+]i in rat sublingual mucous acini by stimulating neurotransmitter release from presynaptic terminals. Proc Soc Exp Biol Med 207:292-301
Bowen, W H; Pearson, S K (1994) Residual effects of fluoride on a severe cariogenic challenge in rats. Caries Res 28:246-50
Adair, S M; Leverett, D H; Shaffer, C L (1994) Interexaminer agreement for readings of dip slide tests for salivary mutans streptococci and lactobacilli. Caries Res 28:123-6
Zhang, G H; Melvin, J E (1994) Intracellular Mg2+ movement during muscarinic stimulation. Mg2+ uptake by the intracellular Ca2+ store in rat sublingual mucous acini. J Biol Chem 269:10352-6
O'Connell, A C; Bowen, W H (1994) Composition and flow rate of saliva and caries development in young rats following administration of lithium. Caries Res 28:342-7

Showing the most recent 10 out of 69 publications