Abstract

This project proposes to define the effects of organ preservation protocols involving high dose radiotherapy (5000+ cGy) with or without chemotherapy on tongue strength and swallowing function in 50 oral tongue and tongue base cancer patients with previously untreated Stages II to IV disease, and to measure the effectiveness of swallow maneuvers in improving the swallow. Each patient will be followed for 12 months after treatment completion. All patients will be studied pretreatment, and at 1 month, 3 months, 6 months and 12 months post completion of chemoradiotherapy. At each of these data collection points, each patient will receive a videofluoroscopic assessment of swallowing and an assessment of tongue strength. The radiographic studies of swallowing will be analyzed in detail for the physiologic swallowing disorders present, and the temporal and biomechanical characteristics of the swallow. Each patient's response to swallow maneuvers will be defined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
3P50DE011921-05S1
Application #
6471779
Study Section
Project Start
2000-08-01
Project End
2002-07-31
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
$103,677
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Cohen, Ezra E W; Rosner, Marsha Rich (2009) MicroRNA-regulated feed forward loop network. Cell Cycle 8:2477-8
Cohen, Ezra E W; Zhu, Hongyan; Lingen, Mark W et al. (2009) A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res 69:65-74
Logemann, Jeri A; Pauloski, Barbara Roa; Rademaker, Alfred W et al. (2008) Swallowing disorders in the first year after radiation and chemoradiation. Head Neck 30:148-58
Huang, R Stephanie; Duan, Shiwei; Kistner, Emily O et al. (2008) Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res 68:3161-8
Zhang, Wei; Duan, Shiwei; Kistner, Emily O et al. (2008) Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet 82:631-40
Shukla, Sunita J; Duan, Shiwei; Badner, Judith A et al. (2008) Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis. Pharmacogenet Genomics 18:253-62
Logemann, Jeri A; Rademaker, Alfred W; Pauloski, Barbara Roa et al. (2006) Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck 28:64-73
Cohen, Ezra Eddy Wyssam; Lingen, Mark W; Zhu, Bangmin et al. (2006) Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res 66:6296-303
Milano, Michael T; Vokes, Everett E; Kao, Johnny et al. (2006) Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol 28:1141-51
Pasche, Boris; Knobloch, Thomas J; Bian, Yansong et al. (2005) Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA 294:1634-46

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