Abstract

Benign Prostatic Hyperplasia (BPH) or Lower Urinary Tract Symptoms (LUTS) represents one of the most common diseases occurring in aging men in the United States. These are complex diseases that require molecular classification and novel therapeutic approaches. To address these needs, we have prepared this application for a George M. O'Brien Urology Center which is focused on BPH/LUTS. The Center consists of four projects each of which is translational/clinical in nature. Project 1 is entitled, Intraprostatic Inflammation in the Etiology of Lower Urinary Tract Symptoms. Project 2 is on JM27 as a Potential Biomarker of Symptomatic BPH. Project 3 relates to Genetic Association Studies in BPH. These three projects are supported by an Administrative and a Bioresource Cores focused on biostatistics. The Administrative Core contains elements of the supporting structure for the Center along with the Pilot and Feasibility and Educational Enrichment Programs. This O'Brien Center should provide new insights and approaches to these common issues that effect almost all men as they age.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center (P50)
Project #
5P50DK082998-02
Application #
7941906
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (O1))
Program Officer
Hoshizaki, Deborah K
Project Start
2009-09-30
Project End
2014-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$1,045,370
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Urology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Na, Rong; Helfand, Brian T; Chen, Haitao et al. (2017) A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Prostate 77:1213-1220
Kulac, Ibrahim; Gumuskaya, Berrak; Drake, Charles G et al. (2016) Peripheral Zone Inflammation Is Not Strongly Associated With Lower Urinary Tract Symptom Incidence and Progression in the Placebo Arm of the Prostate Cancer Prevention Trial?. Prostate 76:1399-408
Torkko, Kathleen C; Wilson, R Storey; Smith, Elizabeth E et al. (2015) Prostate Biopsy Markers of Inflammation are Associated with Risk of Clinical Progression of Benign Prostatic Hyperplasia: Findings from the MTOPS Study. J Urol 194:454-61
Mondul, Alison M; Giovannucci, Edward; Platz, Elizabeth A (2014) A prospective study of obesity, and the incidence and progression of lower urinary tract symptoms. J Urol 191:715-21
Mondul, Alison M; Giovannucci, Edward; Platz, Elizabeth A (2013) A prospective study of statin drug use and lower urinary tract symptoms in older men. Am J Epidemiol 178:797-803
Platz, Elizabeth A; Joshu, Corinne E; Mondul, Alison M et al. (2012) Incidence and progression of lower urinary tract symptoms in a large prospective cohort of United States men. J Urol 188:496-501
Mooney, Steven M; Rajagopalan, Krithika; Williams, Brenten H et al. (2011) Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses. J Cell Biochem 112:1066-75
Rajagopalan, Krithika; Mooney, Steven M; Parekh, Nehal et al. (2011) A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem 112:3256-67
Zeng, Yu; He, Yanan; Yang, Fan et al. (2011) The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem 286:13985-94