Hypertension (central and/or pulmonary) can be the primary cause of cardiac remodeling leading to heart failure (HF). Yet even in circumstances where the primary efiology of HF is in processes intrinsic to the heart, remodeling of the pump and its electromechanical properties will alter the pressures and flows in the cardiovascular system. So we are reminded that comprehensive understanding of complex cardiovascular disease requires the ability to look at (and probe) the system as a whole.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
7P50GM094503-04
Application #
8842784
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$350,760
Indirect Cost
$66,841
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Williams, Nakeya D; Mehlsen, Jesper; Tran, Hien T et al. (2018) An optimal control approach for blood pressure regulation during head-up tilt. Biol Cybern :
Olsen, Christian Haargaard; Ottesen, Johnny T; Smith, Ralph C et al. (2018) Parameter subset selection techniques for problems in mathematical biology. Biol Cybern :
Wright, Peter T; Bhogal, Navneet K; Diakonov, Ivan et al. (2018) Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in ?2AR-cAMP Responsiveness in Murine Hearts. Cell Rep 23:459-469
Ciocanel, Maria-Veronica; Docken, Steffen S; Gasper, Rebecca E et al. (2018) Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation. Biol Cybern :
Qureshi, M Umar; Colebank, Mitchel J; Schreier, David A et al. (2018) Characteristic impedance: frequency or time domain approach? Physiol Meas 39:014004
Herum, Kate M; Choppe, Jonas; Kumar, Aditya et al. (2017) Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell 28:1871-1882
McClymont, Darryl; Teh, Irvin; Carruth, Eric et al. (2017) Evaluation of non-Gaussian diffusion in cardiac MRI. Magn Reson Med 78:1174-1186
Sturdy, Jacob; Ottesen, Johnny T; Olufsen, Mette S (2017) Modeling the differentiation of A- and C-type baroreceptor firing patterns. J Comput Neurosci 42:11-30
Zhang, Yanhang; Barocas, Victor H; Berceli, Scott A et al. (2016) Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Ann Biomed Eng 44:2642-60
Bassingthwaighte, James B; Raymond, Gary M; Dash, Ranjan K et al. (2016) The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen. Adv Exp Med Biol 876:103-110

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