The Microbiology Core Unit is to established to fulfill the following specific objectives: 1. Ongoing support for the P3 (Children's Respiratory Study-CRS) project. This includes continued detection (cultures and/or serologies) of viruses, mycoplasma, ureaplasma, and chlamydia, in order to define, as completely as possible, the causative agents of acute lower respiratory illnesses (LRI) in infants and children. In addition, P3 studies will be extended to include specific investigations of other infectious agents which: 1) may be significantly involved in LRI; 2) may be associated with long term sequelae; and 3) have not yet been systemically sought. These include: a) Human respiratory coronaviruses (OC43 and 229E), including development and applicationof monoclonal antibody methods to detect viral antigens and conduct seroepidemiologic investigations. b) Epstein-Barr virus antigens and conducts seroepidemiologically to define its relative contribution to LRI and long-term sequelae among the P3 subjects, either as a possible primary etiologic agent, or as an associated factor contributing to enhanced susceptibility to other infections. c) Other agents which have not been previously detected by standard methods to date will be investigated seroepidemiologically by the use of indirect immunofluorescent and/or hemagglutination-inhibition methods. These include influenza type C and parainfluenza type 4 viruses. 2. Virologic and serologic support for the P5 and P6 projects.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arizona
United States
Zip Code
Voraphani, Nipasiri; Stern, Debra A; Wright, Anne L et al. (2014) Risk of current asthma among adult smokers with respiratory syncytial virus illnesses in early life. Am J Respir Crit Care Med 190:392-8
Marri, Pradeep Reddy; Stern, Debra A; Wright, Anne L et al. (2013) Asthma-associated differences in microbial composition of induced sputum. J Allergy Clin Immunol 131:346-52.e1-3
Guerra, Stefano; Sherrill, Duane L; Venker, Claire et al. (2010) Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal study. Thorax 65:499-504
Guerra, S; Sherrill, D L; Venker, C et al. (2009) Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk. Thorax 64:894-900