Building on the prior Projects, this last Project will take our investigations of the social decision-making system to the network level and investigate the influences among its components using techniques such as pharmacological inactivation, rare human lesion subjects, diffusion imaging, BOLD coherence and spike-field coherence. It will pave the way for major future efforts, beyond the scope of the present application, eventually to understand the complete functional architecture for social decision-making implemented by a spatially distributed neural system. Specifically, we will focus on how the components of the system identified in the other Projects (e.g., amygdala, dorsolateral and orbital prefrontal cortex) interact. This requires investigations of two kinds: (1) demonstration of the functional effects on one another (Aims 1-2), and (2) characterization of their connectivity (Aims 3-4). This Project features a very close integration of studies in humans and monkeys, uses a diverse set of approaches ranging from diffusion imaging to tracer studies to pharmacological inactivation and spike-field coherence, and leverages many of the data collected under the other Projects. There are four Specific Aims: (1) to characterize interactions between prefrontal and amygdala regions in monkeys and humans using spike-field coherence (collaboration with Dr Doris Tsao);(2) to investigate causal influences of the amygdala on the prefrontal cortex using reversible pharmacological inactivation in monkeys and study of rare human lesion subjects (collaboration with Dr. Richard Andersen);(3) to describe structural and functional connectivity networks in monkeys (4) to describe structural and functional connectivity networks in humans. This final Project thus extends the studies from the prior Projects to the network level, and brings together many of the PIs from the prior Projects.

Public Health Relevance

Many mental illnesses are thought to arise from abnormal connectivity between different brain regions, rather than merely pathology within a region. Autism, for instance, is now often thought of as a disconnection syndrome. This Project will provide important data towards understanding mental illnessess in which abnormal long-range connectivity plays a role in pathology.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
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Special Emphasis Panel (ZMH1-ERB-S (02))
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California Institute of Technology
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Yao, Shuxia; Qi, Song; Kendrick, Keith M et al. (2018) Attentional set to safety recruits the ventral medial prefrontal cortex. Sci Rep 8:15395
Schneider, Brett; Heskje, Jonah; Bruss, Joel et al. (2018) The left temporal pole is a convergence region mediating the relation between names and semantic knowledge for unique entities: Further evidence from a ""recognition-from-name"" study in neurological patients. Cortex 109:14-24
Folkerts, Sarah; Rutishauser, Ueli; Howard, Marc W (2018) Human Episodic Memory Retrieval Is Accompanied by a Neural Contiguity Effect. J Neurosci 38:4200-4211
Cameron, C Daryl; Reber, Justin; Spring, Victoria L et al. (2018) Damage to the ventromedial prefrontal cortex is associated with impairments in both spontaneous and deliberative moral judgments. Neuropsychologia 111:261-268
Mobbs, Dean; Trimmer, Pete C; Blumstein, Daniel T et al. (2018) Foraging for foundations in decision neuroscience: insights from ethology. Nat Rev Neurosci :
Feng, Chunliang; Cao, Jianqin; Li, Yingli et al. (2018) The pursuit of social acceptance: aberrant conformity in social anxiety disorder. Soc Cogn Affect Neurosci 13:809-817
Qi, Song; Hassabis, Demis; Sun, Jiayin et al. (2018) How cognitive and reactive fear circuits optimize escape decisions in humans. Proc Natl Acad Sci U S A 115:3186-3191
Chib, Vikram S; Adachi, Ryo; O'Doherty, John P (2018) Neural substrates of social facilitation effects on incentive-based performance. Soc Cogn Affect Neurosci :
Barrash, Joseph; Stuss, Donald T; Aksan, Nazan et al. (2018) ""Frontal lobe syndrome""? Subtypes of acquired personality disturbances in patients with focal brain damage. Cortex 106:65-80
Beadle, Janelle N; Paradiso, Sergio; Tranel, Daniel (2018) Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering. Front Neurol 9:288

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