The goal of this Motor Neuron Disease (MND) Program Project Grant is to delineate principles underlying the selective vulnerability of the motor neuron. We plan to elucidate motor neuron-specific properties as well as factors that specifically act on motor neurons. The grant topics are: Core A - A clinical and pathological core that acts as a source of clinical information and specimens for members of the Program Project; the core also includes study of the characteristics of MND, the post- poliomyelitis syndrome, and medical ethical issues related to life- sustaining therapy in MND. Project #1 (Siddique) - An RFLP linkage study of familial MND. Project #3 (Gurney) - Neuroleukin (MND growth factor) and its relationship to MND survival and sprouting. Project #4 (Stefansson) Motor neuron-specific proteins and their relationship to motor neuron injury and neurite outgrowth. Project #5 (Roos) - Theiler's virus genes and gene products which determine neurotropism and neurovirulence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS021442-05
Application #
3107795
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1984-12-01
Project End
1992-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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