Abstract

The goal of this Motor Neuron Disease (MND) Program Project Grant is to delineate principles underlying the selective vulnerability of the motor neuron. We plan to elucidate motor neuron-specific properties as well as factors that specifically act on motor neurons. The grant topics are: Core A - A clinical and pathological core that acts as a source of clinical information and specimens for members of the Program Project; the core also includes study of the characteristics of MND, the post- poliomyelitis syndrome, and medical ethical issues related to life- sustaining therapy in MND. Project #1 (Siddique) - An RFLP linkage study of familial MND. Project #3 (Gurney) - Neuroleukin (MND growth factor) and its relationship to MND survival and sprouting. Project #4 (Stefansson) Motor neuron-specific proteins and their relationship to motor neuron injury and neurite outgrowth. Project #5 (Roos) - Theiler's virus genes and gene products which determine neurotropism and neurovirulence.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS021442-05
Application #
3107795
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1984-12-01
Project End
1992-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Haley, Benjamin; Paunesku, Tatjana; Proti?, Miroslava et al. (2009) Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair. Int J Radiat Biol 85:643-55
Thomas, Ajit G; Bodner, Amos; Ghadge, Ghanashyam et al. (2009) GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. J Neurovirol 15:449-57
Paunesku, T; Chang-Liu, C M; Shearin-Jones, P et al. (2000) Identification of genes regulated by UV/salicylic acid. Int J Radiat Biol 76:189-98
Glaum, S R; Brooks, P A (1996) Tetanus-induced sustained potentiation of monosynaptic inhibitory transmission in the rat medulla: evidence for a presynaptic locus. J Neurophysiol 76:30-8
Brooks, P A; Glaum, S R (1995) GABAB receptors modulate a tetanus-induced sustained potentiation of monosynaptic inhibitory transmission in the rat nucleus tractus solitarii in vitro. J Auton Nerv Syst 54:16-26
Glaum, S R; Miller, R J (1995) Presynaptic metabotropic glutamate receptors modulate omega-conotoxin-GVIA-insensitive calcium channels in the rat medulla. Neuropharmacology 34:953-64
Siddique, T (1991) Molecular genetics of familial amyotrophic lateral sclerosis. Adv Neurol 56:227-31