Acute stroke is a common and devastating disorder, the 3rd leading cause of death and leading cause of adult disability in the US. This application for renewal of the UCLA Specialized Program of Translational Research in Acute Stroke Center proposes an integrated research/training program to develop innovative therapies for acute ischemic and hemorrhagic stroke. Five research projects are proposed. Project 1, the Therapeutic Aqueous Oxygen (TAO) Trial' is a 50 patient trial to evaluate the feasibility and safety of endovascular delivery of supersaturated, aqueous oxygen to ischemic human cerebral tissues. This trial will be the first formal study of endovascular infusion of neuroprotective agents, a highly promising complementary strategy to endovascular recanalization. Project 2, the 'Intraoperative CT and Endovascular-Guided Surgery for Intracerebral Hemorrhage (ICES) Trial' is a critical phase 2 trial of a new, minimally invasive surgical technique for the evacuation of primary intracerebral hemorrhage, using mobile intra-operative CT and neuroendoscopy. In addition, studies interrogating the fundamental pathophysiology of brain injury in human ICH are proposed delineating differential gene expression, tissue morphometrics, and multimodal MR signatures in the perihematomal region. In Project 3, 'Telestroke in the Field: Improving Prehospital Stroke Care with Mobile Broadband Telemedicine Technologies,' will evaluate the benefit upon prehospital diagnostic accuracy and informed consent of physician-patient interaction in the field employing emerging video handset technologies. Project 4, 'The MR and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) Trial,' is an international, multicenter pilot trial to determine whether diffusion-perfusion MRI can identify acute cerebral ischemia patients who will benefit substantially from mechanical embolectomy with the Merci Retriever up to 8 hrs from symptom onset. Project 5, the 'Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial' will assess the tolerability, feasibility, and safety of increasing blood flow to ischemic cerebral fields through external counterpulsation in 30 patients with persisting arterial occlusion. Five Cores support the Projects: Administrative, Patient Access, Blood/Tissue Specimen, Biostatistics/Data Management, and Neuroimaging. A Career Development Program will train the next generation of translational scientists in neurovascular disease at the premedical, medical student, and fellowship level.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-G)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Bevers, Matthew B; Battey, Thomas W K; Ostwaldt, Ann-Christin et al. (2018) Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema. Cerebrovasc Dis 45:93-100
Lou, Xin; Yu, Songlin; Scalzo, Fabien et al. (2017) Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke. Oncotarget 8:2437-2443
Nael, Kambiz; Knitter, James R; Jahan, Reza et al. (2017) Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy. Stroke 48:664-670
Sheth, Sunil A; Jahan, Reza; Levy, Elad I et al. (2016) Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomised patients in the SWIFT trial. J Neurointerv Surg 8:347-52
Vespa, Paul; Hanley, Daniel; Betz, Joshua et al. (2016) ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial. Stroke 47:2749-2755
Zhang, Qihui; Yang, Ying; Saver, Jeffrey L (2015) Discharge destination after acute hospitalization strongly predicts three month disability outcome in ischemic stroke. Restor Neurol Neurosci 33:771-5
Liebeskind, David S; Kosinski, Andrzej S; Lynn, Michael J et al. (2015) Noninvasive fractional flow on MRA predicts stroke risk of intracranial stenosis. J Neuroimaging 25:87-91
Shin, Dong-Ick; Lee, Hyung-Suk; Baek, Shin-Hye et al. (2015) Noninvasive Qureshi Grading Scheme Predicts 90-Day mRS in Patients with Acute Ischemic Stroke. J Neuroimaging 25:761-5
Sheth, Sunil A; Jahan, Reza; Gralla, Jan et al. (2015) Time to endovascular reperfusion and degree of disability in acute stroke. Ann Neurol 78:584-93
Parikh, Neal; Merkler, Alexander E; Cheng, Natalie T et al. (2015) Clinical reasoning: an unusual case of subacute encephalopathy. Neurology 84:e33-7

Showing the most recent 10 out of 186 publications