The Blood and Tissue Core provides an essential resource for local and collaborative research. The Core is designed to exist as a """"""""core without walls"""""""". The primary responsibility ofthe Core is to ensure the quality of processing and storage of human specimens. We work closely with the Massachusetts General Hospital's NIH-funded Chnical Research Center (CRC) which is part of the Harvard Clinical and Translational Science Center (CTSC), and we have established collaboration with Dr. James Liao's laboratory at the BWH. We propose a Blood and Tissue Core responsive to the aims set forth in the Specialized Program of Translational Research in Acute Stroke program announcement (PAR-09-254), which will support ARISE (project #2) at MGH and Neu-START at BWH, and collect and share plasma and DNA samples within the SPOTRIAS network.
The aims ofthe Partners SPOTRIAS Blood and Tissue Core are: 1. To process, maintain, and distribute blood specimens collected in ARISE (Project #2) at MGH. 2. To support blood collection and processing for the Neu-START study at the BWH. 3. To store blood specimens collected on SPOTRIAS subjects for future collaborative studies. 4. To collect genetic material for submission to the NINDS repository for use in future genetic studies proposed within Partners, the SPOTRIAS network, the International Stroke Genetics Consortium (ISGC), and the broader scientific community.

Public Health Relevance

Biomarkers in acute stroke appear promising in developing targets for neuroprotective therapies, monitoring response to treatment and as surrogate endpoints for clinical trials. For example, hemostatic and inflammatory biomarkers appear to correlate with response to thrombolysis, infarct progression and hemorrhage transformation. Future studies in acute stroke are needed to define their role in clinical practice.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Special Emphasis Panel (ZNS1)
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Massachusetts General Hospital
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Murphy, Meredith P; Kuramatsu, Joji B; Leasure, Audrey et al. (2018) Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 49:2652-2658
Schwamm, Lee H; Wu, Ona; Song, Shlee S et al. (2018) Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results. Ann Neurol 83:980-993
Rost, Natalia S; Cougo, Pedro; Lorenzano, Svetlana et al. (2018) Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab 38:75-86
Lorenzano, Svetlana; Rost, Natalia S; Furie, Karen L (2018) Response by Lorenzano et al to Letter Regarding Article, ""Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke"". Stroke 49:e264
Matsouaka, Roland A; Singhal, Aneesh B; Betensky, Rebecca A (2018) An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res 27:2384-2400
Lorenzano, Svetlana; Rost, Natalia S; Khan, Muhib et al. (2018) Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke. Stroke 49:630-637
Atem, Folefac D; Qian, Jing; Maye, Jacqueline E et al. (2017) Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study. J R Stat Soc Ser C Appl Stat 66:313-328
Dumitrascu, Oana M; Torbati, Sam; Tighiouart, Mourad et al. (2017) Pitfalls and Rewards for Implementing Ocular Motor Testing in Acute Vestibular Syndrome: A Pilot Project. Neurologist 22:44-47
Marini, Sandro; Morotti, Andrea; Ayres, Alison M et al. (2017) Sex differences in intracerebral hemorrhage expansion and mortality. J Neurol Sci 379:112-116
Etherton, Mark R; Wu, Ona; Cougo, Pedro et al. (2017) Structural Integrity of Normal Appearing White Matter and Sex-Specific Outcomes After Acute Ischemic Stroke. Stroke 48:3387-3389

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