Core A, the Administrative Core of this National Institute of Neurological Disorders and Stroke (NINDS) Morris K. Udall Parkinson's Disease Research Center of Excellence (Udall Center) at the University of Pennsylvania (Penn), will facilitate accomplishing the goals of this multidisciplinary research program. Briefly, the goals of this Udall Center are to elucidate mechanisms of progressive neurodegeneration in Parkinson's disease (PD), especially those mechanisms underlying the cognitive and executive impairments in PD patients without and with dementia (PDD) and in dementia with Lewy bodies (DLB) patients. We hypothesize that disease progression leads to neuron dysfunction and death resulting from the differential transmission of pathologic alpha-synuclein species or strains and their neurotoxic effects in patients with PD/PDD/DLB. Thus, the Aims of Core A are to oversee budgetary and fiscal aspects of this Udall Center;promote and foster interactions between Core and Project investigators, as well as interactions of Udall Center investigators with scientists outside the Center at and beyond Penn;monitor the progress of the Cores and Projects;facilitate the sharing of data, reagents, and resources generated by Penn Udall Center investigators with other researchers in accordance with NIH policies;and participate in annual Udall Center meetings to accelerate the pace of advances in understanding PD/PDD/DLB. By utilizing the strategies in these Aims, Core A will play an important administrative role in this Udall Center by fostering the accomplishment of its overall mission..

Public Health Relevance

Core A is highly relevant to the mission of the Penn Udall Center because it supports the efforts of each of the Cores and Projects in the Center to challenge and re-define current understanding of and research on PD/PDD/DLB by implementing the Specific Aims of Core A.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS053488-07
Application #
8534824
Study Section
Special Emphasis Panel (ZNS1-SRB-J)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$75,836
Indirect Cost
$24,087
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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