Core A. Administrative Core. The Administrative Core will serve to coordinate and support the activities of the Center in its entirety by facilitating communication between the PI, projects, cores, intemal advisors, external advisors, other Udall Centers, and the public. Salary support is requested for two individuals: The Center PI, Dr. Timothy Collier, and the Administrative Coordinator, Ms Michelle Gartland. Dr. Collier's effort will be devoted to oversight of the Core's activities, and participation in decision-making related to mechanisms for tracking progress and fiiture directions of the Center's scientific activities. This includesfrequentmeetings with Project Leaders and staff, annual meetings with intemal advisors and representatives of existing Udall Centers, bi-annual meetings with external advisors, and semi-annual revision of website content to communicate Center activities to the public. Day-to-day management of administrative activities (the real work) will be carried out by Ms. Michelle Gartland. Ms. Gartland has worked as an administrative/research assistant with Drs. Collier and Sortwell for five years. Her familiarity with both types of activities provides a significant advantage in execution of this role for the Center. In summary, the primary flmction of Core A is to enable communication. This will be achieved by 1) providing administrative support for the projects and cores, 2) scheduling and providing support for meetings between Center project leaders and intemal and external advisors, 3) facilitating travel and communication of data at annual Udall Centers meetings and meetings of national and international scientific societies, and 4) creating and maintaining a Center website. Ms. Gartland is experienced and talented in design of power point presentations and websites. These skills will enable center investigators to effectively communicate progress both to colleagues and to the public. The Center website will be the centerpiece of our group commitment to transparency in the use of Center funds as they apply to health and well-being of individuals with Parkinson's disease.

Public Health Relevance

Core A provides the administrative structure to promote the educational and informational mission of Udall Center activities for patients with Parkinson's disease and the Cincinnati community at large.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Michigan State University
East Lansing
United States
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Collier, Timothy J; Srivastava, Kinshuk R; Justman, Craig et al. (2017) Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiol Dis 106:191-204
Fischer, D Luke; Manfredsson, Fredric P; Kemp, Christopher J et al. (2017) Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal ?-Synuclein Overexpression. Sci Rep 7:16356
Fischer, D Luke; Kemp, Christopher J; Cole-Strauss, Allyson et al. (2017) Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration. J Neurosci 37:6786-6796
Ventorp, Filip; Bay-Richter, Cecilie; Nagendra, Analise Sauro et al. (2017) Exendin-4 Treatment Improves LPS-Induced Depressive-Like Behavior Without Affecting Pro-Inflammatory Cytokines. J Parkinsons Dis 7:263-273
Kneynsberg, Andrew; Collier, Timothy J; Manfredsson, Fredric P et al. (2016) Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures. J Neurosci Methods 266:32-41
Polinski, Nicole K; Manfredsson, Fredric P; Benskey, Matthew J et al. (2016) Impact of age and vector construct on striatal and nigral transgene expression. Mol Ther Methods Clin Dev 3:16082
Madhavan, Lalitha; Daley, Brian F; Davidson, Beverly L et al. (2015) Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PLoS One 10:e0137136
Grabinski, Tessa M; Kneynsberg, Andrew; Manfredsson, Fredric P et al. (2015) A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. PLoS One 10:e0120120
Fischer, D Luke; Collier, Timothy J; Cole-Strauss, Allyson et al. (2015) High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. PLoS One 10:e0133957
Paumier, Katrina L; Luk, Kelvin C; Manfredsson, Fredric P et al. (2015) Intrastriatal injection of pre-formed mouse ?-synuclein fibrils into rats triggers ?-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol Dis 82:185-199

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