The 5-year renewal for Grant P51 RR00163-50 requests funding for programs at the ONPRC that support biomedical research. The application reflects a new strategic focus on interdisciplinary research to optimize the use and development of nonhuman primate (NHP) models.
The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which NHPs are used to accelerate progress in understanding human diseases;2) enhance the Center's resources (scientific expertise, laboratories, animal services, research support cores and equipment) so as to serve as a regional and national resource;3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-origin rhesus macaque breeding program;and 4) expand research programs utilizing NHPs in stem cell biology, aging, obesity, genetics, infectious diseases, vaccine development, neuroscience and women's health. To accomplish these aims, support is requested in three broad areas. First, Administration &Center Operations provide the administrative and service support required for all aspects of the ONPRC. Units include: 1) the Director's Office;2) Administrative Services (Business Services, Environmental Health &Radiation Safety, Facilities &Property, Information Technology &Engineering, and the Research Library);3) Animal Resources (Administration, Operations, Behavioral Services, Pathology Services, Surgery Services, and Clinical Medicine);and 4) Research Support Cores (Assisted Reproductive Technology, Endocrine Technology, Imaging &Morphology, Immunology, Magnetic Resonance Imaging, Molecular &Cellular Biology, and Virology &Serology). Secondy, Scientific Components include support for: 1) Scientific Divisions (Neuroscience, Pathobiology &Immunology, and Reproductive Sciences) and their interdisciplinary Working Groups (Biology of Aging, Metabolic Disease, and Stem Cell &Developmental Biology);2) the Collaborative Research Unit that facilitates externallyfunded research;3) the Pilot Project Program;and 4) Resource-Related Research. Finally, Improvement & Modernization includes funds for equipment and alterations and renovations.
The funds requested will provide support for the research infrastructure required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, including increased biodefense and HIV vaccine research, as well as translational research initiatives that are highly interdisciplinary in nature.
|Noguchi, Kevin K; Johnson, Stephen A; Manzella, Francesca M et al. (2018) Caffeine Augments Anesthesia Neurotoxicity in the Fetal Macaque Brain. Sci Rep 8:5302|
|Coleman, Kristine; Robertson, Nicola D; Maier, Adriane et al. (2018) Effects of Immediate or Delayed Estradiol on Behavior in Old Menopausal Macaques on Obesogenic Diet. J Obes 2018:1810275|
|Bulgarelli, Daiane L; Ting, Alison Y; Gordon, Brenda J et al. (2018) Development of macaque secondary follicles exposed to neutral red prior to 3-dimensional culture. J Assist Reprod Genet 35:71-79|
|Lindner, Jonathan R (2018) Microvascular Dysfunction and Clinical Outcomes. Circ Cardiovasc Imaging 11:e008381|
|True, Cadence; Dean, Tyler; Takahashi, Diana et al. (2018) Maternal High-Fat Diet Effects on Adaptations to Metabolic Challenges in Male and Female Juvenile Nonhuman Primates. Obesity (Silver Spring) 26:1430-1438|
|Scully, C M; Estill, C T; Amodei, R et al. (2018) Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior. Domest Anim Endocrinol 62:1-9|
|Haigwood, Nancy L (2018) Antibodies pose a double threat to HIV. Nature 561:468-470|
|Edelman, Alison B; Jensen, Jeffrey T; McCrimmon, Sara et al. (2018) Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception 98:463-466|
|Jimenez, Vanessa A; Wang, Xiaojie; Newman, Natali et al. (2018) Detecting neurodevelopomental effects of early-gestation ethanol exposure: a non-human primate model of ethanol drinking during pregnancy. Alcohol Clin Exp Res :|
|Jeon, Sookyoung; Ranard, Katherine M; Neuringer, Martha et al. (2018) Lutein Is Differentially Deposited across Brain Regions following Formula or Breast Feeding of Infant Rhesus Macaques. J Nutr 148:31-39|
Showing the most recent 10 out of 547 publications