This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Despite the effectiveness of antiretroviral therapy in controlling virus replication in blood, it fails to 'clear' HIV-1 infection from patients, indicating the existence of a refractory viral reservoir(s). Clearly blood is not the major source of virus as several studies have shown the frequency of infected cells in blood is extremely low, even in patients with persistent plasma viremia. A few studies have demonstrated that lymph nodes (LN) as a viral reservoir in HIV-infected patients, and indeed higher frequencies of infected cells are observed in LN compared to blood, but in some individuals, infected cells are also undetectable in LN, particularly in patients who are controlling infection. These findings, combined with our preliminary data, suggest that other tissues serve as major viral reservoirs, particularly the intestinal inductive lymphoid tissues. Identifying and quantifying the relative contribution of the major reservoirs and determining whether there are differences in tissue or cellular reservoirs between long term nonprogressors and those who progress to AIDS is a logical 'first step' for designing strategies to combat these reservoirs. These studies will assess and compare the major tissue and cellular reservoirs for SIV/SHIV infection. We expect these data will be directly applicable to both treatment and vaccine studies, in that these results may focus these efforts towards the most relevant tissue and cellular reservoirs. At present, we cannot draw definitive conclusions on the distribution and phenotype of reservoir cells but are making excellent progress and expect to finish the proposed project within the stipulated time frame.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000164-46
Application #
7562359
Study Section
Special Emphasis Panel (ZRR1-CM-9 (01))
Project Start
2007-05-01
Project End
2008-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
46
Fiscal Year
2007
Total Cost
$71,639
Indirect Cost
Name
Tulane University
Department
Pathology
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Parthasarathy, Geetha; Philipp, Mario T (2018) Intracellular TLR7 is activated in human oligodendrocytes in response to Borrelia burgdorferi exposure. Neurosci Lett 671:38-42
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Yi, Fei; Guo, Jia; Dabbagh, Deemah et al. (2017) Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol 91:
Jorgensen, Matthew J; Lambert, Kelsey R; Breaux, Sarah D et al. (2017) Pair housing of Vervets/African Green Monkeys for biomedical research. Am J Primatol 79:1-10
Ramesh, Geeta; Martinez, Alejandra N; Martin, Dale S et al. (2017) Effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in glial and neuronal cells of the central nervous system. J Neuroinflammation 14:28
Parthasarathy, Geetha; Philipp, Mario T (2017) Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi. J Neuroinflammation 14:110

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