This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The goal of this project is to test two candidate vaccines for protection of macaques against Simian Type D Retrovirus (SRV). If successful, this may be helpful in preventing a common spontaneous retrovirus induced immunosuppressive disease in macaques. Infection with SRV is prevalent in wild and has been common in captive macaques and is capable of causing an AIDS like disease in simians. Rapidly spread through body fluids (saliva or blood), SRV can cause an endemic infection of wild and captive macaques colonies. There are currently four animals on this study. In phase 1, two animals will be inoculated IV with SRV. Blood samples, lymph node and intestinal biopsies and saliva swabs will be collected prior to and post-inoculation to monitor SRV infection and pathogenesis as well as to test for antibody and immune responses to inoculation. In phase 2, eight animals will be used in a vaccine study using an Adenovirus prime, VSV boost vaccine strategy.
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