This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The PI has a strong interest in the molecular and neural mechanisms underlying behavior and uses a wide range of experimental techniques, from behavioral and pharmacological to molecular and transgenic techniques, to address important behavioral neuroscience questions. Currently, research focuses on the role of neuropeptides in the modulation of social behaviors and attachment. Vasopressin (AVP) facilitates affiliation and pair bond formation in monogamous species. Compared to non-monogamous species, monogamous species have high levels of AVP receptors in the ventral pallidum, a brain region associated with reinforcement and reward. Enhancing AVP receptor gene expression in the ventral pallidum using viral vector gene transfer facilitates pair bonding in the male prairie vole. This has led to the hypothesis that vasopressin stimulates social attachment by activating reward circuits via activation of AVP receptors in the ventral pallidum.
The specific aims of this project will investigate the role of the ventral pallidum in social attachment and characterize the activity, phenotype, and connectivity of vasopressin receptor containing cells in this region. Further studies will investigate the molecular mechanisms controlling AVP receptor expression in the ventral pallidum. Understanding the link between social interactions, reward circuitry and social attachment may provide useful insights into potential mechanisms underlying psychiatric diseases characterized by social deficits, such as autism.
|Meng, Yuguang; Hu, Xiaoping; Zhang, Xiaodong et al. (2018) Diffusion tensor imaging reveals microstructural alterations in corpus callosum and associated transcallosal fiber tracts in adult macaques with neonatal hippocampal lesions. Hippocampus 28:838-845|
|Mylvaganam, Geetha H; Chea, Lynette S; Tharp, Gregory K et al. (2018) Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV. JCI Insight 3:|
|Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826|
|Ploquin, Mickaël J; Casrouge, Armanda; Madec, Yoann et al. (2018) Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage. J Int AIDS Soc 21:e25144|
|Fonseca, Jairo A; McCaffery, Jessica N; Caceres, Juan et al. (2018) Inclusion of the murine IgG? signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine. Vaccine 36:2799-2808|
|Tedesco, Dana; Thapa, Manoj; Chin, Chui Yoke et al. (2018) Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic ?? T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology 154:2178-2193|
|Robinson, Amy A; Abraham, Carmela R; Rosene, Douglas L (2018) Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. Geroscience 40:31-47|
|Walker, Lary C (2018) Sabotage by the brain's supporting cells helps fuel neurodegeneration. Nature 557:499-500|
|Mascaro, Jennifer S; Rentscher, Kelly E; Hackett, Patrick D et al. (2018) Preliminary evidence that androgen signaling is correlated with men's everyday language. Am J Hum Biol 30:e23136|
|Forger, Nancy G; Ruszkowski, Elara; Jacobs, Andrew et al. (2018) Effects of sex and prenatal androgen manipulations on Onuf's nucleus of rhesus macaques. Horm Behav 100:39-46|
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