This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.To provide core, campus and non-host investigators with sophisticated and specialized pathology resources and expertise.1. Progress and concernsThe WNPRC has two part time pathologists and is conducting a search for a third pathologist. The unit has continued to function smoothly during 2007. Unit members have participated in the submission of 2 RO1 grants for the further development of the Primate Pathology Image Database and for the development of Primate Pathology Ontology. Members have provided training to scientists and staff at a primate research facility in China and will continue to work with Chinese collaborators in 2008. 2. Allocation of Resource AccessPathology Services notifies investigators of the resource via the Primate Center website, scientific meetings, and through the nonhuman primate biological materials distribution program. To date, no requests have been denied. All core WNPRC labs use Pathology Services at some point in their projects, and numerous campus affiliates avail of this service. In addition, since May 1, 2007, 20 investigators from non-host institutions received a total of 129 samples total, representing tissues, organs and genetic material from Macaca mulatta and Callithrix jacchus. Of these, 45 samples went to PIs at non-host institutions and without subprojects in this year's APR. Please see the Research Services section of this progress report for a table of non host, non-subproject species, specimen types and numbers, as required by APR reporting instructions.3. DisseminationWe request that projects utilizing Pathology Services acknowledge the service in manuscripts and presentations. The unit's pathologists also lecture regularly on primate pathology to WNPRC staff, veterinary pathology residents on campus, and to veterinary students. One unit member presented a short outreach program to a local Girl Scout troop that involved the creation of enrichment toys for animals and a follow-up meeting so that the children could see the results of their work. 4. TrainingIn 2007 Pathology Unit members participated in clinical pathology training to provide additional services for colony management. Unit members provided training in specialized NHP necropsy procedures to campus pathologists and multiple consultations on NHP cases.Unit members provided preparatory training for the American College of Veterinary Pathologists certifying examination to four pathology residents on campus. PublicationsPathology Services has contributed to numerous publications that involved use in part or in full of the WNPRC.Note: AIDS related

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000167-47A1
Application #
7716452
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2008-07-23
Project End
2009-04-30
Budget Start
2008-07-23
Budget End
2009-04-30
Support Year
47
Fiscal Year
2008
Total Cost
$81,915
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kang, HyunJun; Mesquitta, Walatta-Tseyon; Jung, Ho Sun et al. (2018) GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition. Stem Cell Reports 11:197-211
Rhoads, Timothy W; Burhans, Maggie S; Chen, Vincent B et al. (2018) Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys. Cell Metab 27:677-688.e5
Ellis-Connell, Amy L; Balgeman, Alexis J; Zarbock, Katie R et al. (2018) ALT-803 Transiently Reduces Simian Immunodeficiency Virus Replication in the Absence of Antiretroviral Treatment. J Virol 92:
Park, Mi Ae; Jung, Ho Sun; Slukvin, Igor (2018) Genetic Engineering of Human Pluripotent Stem Cells Using PiggyBac Transposon System. Curr Protoc Stem Cell Biol 47:e63
Ellis, Amy; Balgeman, Alexis; Rodgers, Mark et al. (2017) Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacterium tuberculosis-Infected Mauritian Cynomolgus Macaques. Infect Immun 85:
Rodrigues, Michelle A (2017) Female Spider Monkeys (Ateles geoffroyi) Cope with Anthropogenic Disturbance Through Fission-Fusion Dynamics. Int J Primatol 38:838-855
Buechler, Connor R; Bailey, Adam L; Lauck, Michael et al. (2017) Genome Sequence of a Novel Kunsagivirus (Picornaviridae: Kunsagivirus) from a Wild Baboon (Papio cynocephalus). Genome Announc 5:
Wu, Hong; Whritenour, Jessica; Sanford, Jonathan C et al. (2017) Identification of MHC Haplotypes Associated with Drug-induced Hypersensitivity Reactions in Cynomolgus Monkeys. Toxicol Pathol 45:127-133
Shackman, A J; Fox, A S; Oler, J A et al. (2017) Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Mol Psychiatry 22:724-732
Kalin, Ned H (2017) Mechanisms underlying the early risk to develop anxiety and depression: A translational approach. Eur Neuropsychopharmacol 27:543-553

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