Significance We have continued our studies of Helicobactor pylori infection in rhesus macaques using the urea breath test (the application of which we have adapted to non-human primates), gastric biopsy techniques (including culture, histology, and PCR), and drug treatment of infected animals. Objectives Our objectives continue to revolve around a better understanding of the natural history of infection with H pylori in order to facilitate treatment and prevention of this disease in humans where it can cause gastric ulcers and neoplasia. Our most significant recent accomplishments include the development of a sensitive and specific serologic assay for H pylori in rhesus macaques, and the finding that the urea breath test, a test receiving increasing application in humans for the diagnosis of H pylori infection, is not sensitive for the detection of early (experimental) infection. Future Directions Future goals include identification of a human isolate of H pylori which will infect rhesus macaques in order to improve our primate model and elucidation of the mechanism of transfer of this infection among animals. KEYWORDS Helicobactor pylori, immunization

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000169-37
Application #
6277857
Study Section
Project Start
1998-05-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
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