The research program of the California Primate Research Center will be focused in areas selected for relevance to human health. The research is broad in scope but emphasizes problems for which the nonhuman primate is the appropriate animal model. Investigations are carried out at the behavioral, physiological, biochemical and molecular levels. Studies of normal and abnormal functions are performed and spontaneous diseases as well as experimentally-induced disorders are investigated. There is a longstanding research interest in the adverse effects of environmental factors. Social dynamics are studied under field and laboratory conditions. The major program units will be Behavioral Biology (social organization, interspecies, differences, psychosocial development, maternal/infant behavior and development); Developmental and Reproductive Biology (gamete biology and fertilization, early embryonic differentiation and implantation, reproductive immunology, endocrinology and toxicology, contraceptive development); Respiratory Diseases (environmental oxidants and other air pollutants, cellular biology and molecular biology of the lung); Comparative Retrovirology (clinical and basic research in human and simian AIDS); Virology and Immunology (simian AIDS, pathogenesis, mechanisms of immunopathogenesis, lentiviruses, genetic determinants of immunosuppressive disease); and Comparative Primate Biology (hepatic physiopathology, comparative genetics, environmental physiology, intravital and quantitative microscopy and a variety of biomedical collaborative research projects). Primate Services (the major support unit, is composed of teams of specialists responsible for the high quality of animal care and ensures the humane treatment of animals. This unit also conducts studies to determine the most optimal approaches for handling and housing of animals in a research setting). There is considerable interaction between the research units, particularly the units for Comparative Retrovirology and Virology and Immunology.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
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Special Emphasis Panel (CM)
Program Officer
Robinson, Jerry
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University of California Davis
Schools of Veterinary Medicine
United States
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Comrie, Alison E; Gray, Daniel T; Smith, Anne C et al. (2018) Different macaque models of cognitive aging exhibit task-dependent behavioral disparities. Behav Brain Res 344:110-119
Day, George Q; Ng, Jillian; Oldt, Robert F et al. (2018) DNA-based Determination of Ancestry in Cynomolgus Macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci 57:432-442
Carroll, Timothy D; Jegaskanda, Sinthujan; Matzinger, Shannon R et al. (2018) A Lipid/DNA Adjuvant-Inactivated Influenza Virus Vaccine Protects Rhesus Macaques From Uncontrolled Virus Replication After Heterosubtypic Influenza A Virus Challenge. J Infect Dis 218:856-867
Midic, Uros; VandeVoort, Catherine A; Latham, Keith E (2018) Determination of single embryo sex in Macaca mulatta and Mus musculus RNA-Seq transcriptome profiles. Physiol Genomics 50:628-635
Almodovar, Sharilyn; Swanson, Jessica; Giavedoni, Luis D et al. (2018) Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol 31:206-222
Ciupe, Stanca M; Miller, Christopher J; Forde, Jonathan E (2018) A Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaques. Front Microbiol 9:1216
Feng, Jun-Feng; Liu, Jing; Zhang, Lei et al. (2017) Electrical Guidance of Human Stem Cells in the Rat Brain. Stem Cell Reports 9:177-189
Han, Pengcheng; Nielsen, Megan; Song, Melissa et al. (2017) The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques. Front Aging Neurosci 9:180
Pittet, Florent; Johnson, Crystal; Hinde, Katie (2017) Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta). Am J Phys Anthropol 164:457-476
Kyle, Colin T; Stokes, Jared; Bennett, Jeffrey et al. (2017) Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. Hippocampus :

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