TheAnimalModelsCoreofTheScrippsResearchInstituteAlcoholResearchCenter(TSRI-ARC)willprovide a variety of behavioral and bioanalytical services to meet the specific needs of the Center at large. The first goaloftheAnimalModelsCoreistoprovideanimalsthataredependentorhaveahistoryofdependenceon alcohol after chronic intermittent ethanol vapor exposure (CIE model) to TSRI-ARC and Center at Large investigators (Specific Aim 1). The core will also supervise all changes in equipment, procedures, and any refinement of the current animal models to ensure that standardized procedures are used across all laboratories. The second goal of the Animal Models Core is to perform biochemical measurements, such as blood alcohol, cortisol/corticosterone, and estrous cycle phase determinations in support of all ARC-related projectsandestablishanalcoholbiobankthatwillprovidetissuestoNIH-fundedinvestigatorsandacademicor non-profit research institutions (Specific Aim 2). The last goal of the Animal Models Core is to provide preclinical testing to all TSRI-ARC PIs and determine the dose range of efficacy of novel compounds to be testedintheclinicalcomponentoftheTSRI-ARC(SpecificAim3).TheAnimalModelsCorewillenableARC investigators to enrich the interpretational power of their experiments through standardized models, standardizedbiologicalanalyses,andpreclinicaltestingcapabilities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA006420-37
Application #
9836776
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
37
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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