Abstract

TheAnimalModelsCoreofTheScrippsResearchInstituteAlcoholResearchCenter(TSRI-ARC)willprovide a variety of behavioral and bioanalytical services to meet the specific needs of the Center at large. The first goaloftheAnimalModelsCoreistoprovideanimalsthataredependentorhaveahistoryofdependenceon alcohol after chronic intermittent ethanol vapor exposure (CIE model) to TSRI-ARC and Center at Large investigators (Specific Aim 1). The core will also supervise all changes in equipment, procedures, and any refinement of the current animal models to ensure that standardized procedures are used across all laboratories. The second goal of the Animal Models Core is to perform biochemical measurements, such as blood alcohol, cortisol/corticosterone, and estrous cycle phase determinations in support of all ARC-related projectsandestablishanalcoholbiobankthatwillprovidetissuestoNIH-fundedinvestigatorsandacademicor non-profit research institutions (Specific Aim 2). The last goal of the Animal Models Core is to provide preclinical testing to all TSRI-ARC PIs and determine the dose range of efficacy of novel compounds to be testedintheclinicalcomponentoftheTSRI-ARC(SpecificAim3).TheAnimalModelsCorewillenableARC investigators to enrich the interpretational power of their experiments through standardized models, standardizedbiologicalanalyses,andpreclinicaltestingcapabilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA006420-37
Application #
9836776
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
37
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Matzeu, Alessandra; Terenius, Lars; Martin-Fardon, Remi (2018) Exploring Sex Differences in the Attenuation of Ethanol Drinking by Naltrexone in Dependent Rats During Early and Protracted Abstinence. Alcohol Clin Exp Res 42:2466-2478
Kononoff, Jenni; Melas, Philippe A; Kallupi, Marsida et al. (2018) Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep 8:13893
Verheij, Michel M M; Contet, Candice; Karel, Peter et al. (2018) Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry 83:1024-1035
Schmeichel, Brooke E; Matzeu, Alessandra; Koebel, Pascale et al. (2018) Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology 43:2373-2382
Kononoff, Jenni; Kallupi, Marsida; Kimbrough, Adam et al. (2018) Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro 5:
Kreisler, A D; Mattock, M; Zorrilla, E P (2018) The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 130:59-69
Varodayan, F P; Khom, S; Patel, R R et al. (2018) Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress. Alcohol Alcohol 53:642-649
McClatchy, Daniel B; Yu, Nam-Kyung; Martínez-Bartolomé, Salvador et al. (2018) Structural Analysis of Hippocampal Kinase Signal Transduction. ACS Chem Neurosci :
Berger, Anthony L; Henricks, Angela M; Lugo, Janelle M et al. (2018) The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. Biol Psychiatry 84:611-623
Mason, Barbara J; Quello, Susan; Shadan, Farhad (2018) Gabapentin for the treatment of alcohol use disorder. Expert Opin Investig Drugs 27:113-124

Showing the most recent 10 out of 211 publications