TheInformationDisseminationCoreofTheScrippsResearchInstituteAlcoholResearchCenter(TSRI-ARC) willdisseminatescientificresearchfindingsmadebyARClabstothepublicthrougheducationalandoutreach efforts and will particularly target NIAAA-identified ?Special Populations? (youth under age 21, college-age young adults, senior citizens, women, and ethnic and racial minorities) that have characteristics that make themmoresusceptibletothenegativeconsequencesofalcoholuse.Importantly,thesepopulationsalsoareat high risk for stress, the primary focus of TSRI-ARC.
Core Specific Aims are the 1) Development of curricula targeted to high-risk populations, 2) Expansion of internships targeted to high-risk populations, and 3) Outreachthroughenhancedsocialmediaandparenteducation.Thegoalsoftheseaimsaretototeachhigh- riskpopulationsandthosewhointeractwiththemhowthebrainisaffectedbyalcohol,theprogressionofthese effectswithcontinueduse,andtheconceptofthe?darkside?ofaddictionusingspecificexamplesfromTSRI- ARC laboratories, to directly interact with the community through laboratory tours and a continuation and expansionofourinternshipprogram,andtomaketheTSRI-ARCwebsitemoreaccessibletothepublicandto use it for communication between TSRI-ARC PIs as well as a critical resource for each of our curriculum efforts.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAA1)
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Scripps Research Institute
La Jolla
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Matzeu, Alessandra; Martin-Fardon, Rémi (2018) Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus. Front Neurol 9:720
Sidhu, Harpreet; Kreifeldt, Max; Contet, Candice (2018) Affective Disturbances During Withdrawal from Chronic Intermittent Ethanol Inhalation in C57BL/6J and DBA/2J Male Mice. Alcohol Clin Exp Res 42:1281-1290
Ehlers, Cindy L; Wills, Derek; Gilder, David A (2018) A history of binge drinking during adolescence is associated with poorer sleep quality in young adult Mexican Americans and American Indians. Psychopharmacology (Berl) 235:1775-1782
Pavon, Francisco J; Serrano, Antonia; Sidhpura, Nimish et al. (2018) Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addict Biol 23:723-734
Logrip, Marian L; Walker, John R; Ayanwuyi, Lydia O et al. (2018) Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism. Front Psychiatry 9:28
Serrano, Antonia; Pavon, Francisco J; Buczynski, Matthew W et al. (2018) Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology 43:1840-1850
Spierling, Samantha R; Kreisler, Alison D; Williams, Casey A et al. (2018) Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability. Physiol Behav 192:3-16
Blasio, Angelo; Wang, Jingyi; Wang, Dan et al. (2018) Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice. Biol Psychiatry 84:193-201
Kirson, Dean; Oleata, Christopher Shaun; Parsons, Loren Howell et al. (2018) CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 23:676-688
Matzeu, Alessandra; Kallupi, Marsida; George, Olivier et al. (2018) Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology 43:1010-1020

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