Human Alcohol Seeking Despite Aversion Prolonged alcohol use results in neuroadaptations leading to decreased sensitivity to alcohol, a shift from positive to negative reinforcement-based alcohol use, increased negative affect that drives further consumption, and, ultimately, aversion-resistant drinking. Aversion resistant drinking is a hallmark of more severe and treatment-resistant persistent alcohol use. It has been widely studied in animal models, but has not been well characterized in humans. This project aims to develop an objective measure of aversion resistant drinking in humans, modeled as alcohol self-administration despite aversion, and to characterize its underlying neural signatures. The positive impact of this project will be to advance the translation between preclinical models and clinical models, and to elucidate distinct mechanisms underlying alcohol use disorder progression in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA007611-33
Application #
9828762
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
33
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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