The Animal Core Component will oversee care and use of rhesus macaques (Macaca mulatta) used by CARC investigators to study the impact of alcohol consumption on SIV disease prevention, shedding, progression as affected by treatment with anti-retroviral drugs. In addition, this core will extend its expertise and coordination of data collection to satellite projects using our alcohol/SIV infection model and CARC projects. The purpose of this Animal Core Component will be to provide high quality care, treatment and monitoring of rhesus macaques and to coordinate studies in order to maximally utilize this precious and unique resource.
The Specific Aims of the Animal Core will be: 1) To perform all aspects of care, treatment and monitoring of rhesus macaques that will be used by Research Component and Pilot Research investigators of the CARC in order to study the impact of chronic alcohol consumption on SIV disease transmission, pathogenesis, progression and ART. 2) To coordinate experimental design protocols among CARC Research Components (and satellite projects) using our alcohol/SIV infection model in rhesus macaques. 3) To schedule and coordinate sample collections from rhesus macaques and their distribution to Lab Core, Research Component and Pilot Project personnel of the CARC for analysis. 4. To serve as a resource for investigators that want to study the impact of alcohol on HIV disease using NHP models. The Animal Core Director, Gregory J. Bagby, PhD, will oversee and coordinate the use of this precious animal resource. The day-to-day management of research involving macaques will be performed by Co-Director Jason Dufour, DVM, DACLAM at TNPRC. The Animal Core will draw upon the interests and expertise of several scientists within and outside the CARC in conducting alcohol research using the rhesus macaque model of HIV disease, and be responsive to the Intramural Center Committee (ICC) in prioritizing the long-term activities of this Core. The members of the ICC will have the authority to modify plans and determine if long-term goals or priorities should be altered. An overall goal of this Animal Core will be to enhance efficiency, quality control, cooperation, and flexibility of research participants in their pursuit of ARC.

Public Health Relevance

The Animal Core Component of our Comprehensive Alcohol Research Center (CARC) will perform an essential role in supporting and coordinating care and use of rhesus macaques {Macaca mulatta) used by 5 Research Components and Pilot Projects that study the effect of chronic alcohol consumption on simian immunodeficiency virus (SIV) disease and its control by anti-retroviral therapy (ART). The SIV rhesus monkey model is broadly recognized for its similarities to HIV/AIDS in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA009803-21
Application #
8577109
Study Section
Special Emphasis Panel (ZAA1-DD)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
21
Fiscal Year
2014
Total Cost
$341,049
Indirect Cost
$29,913
Name
Louisiana State Univ Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Molina, Patricia E; Nelson, Steve (2018) Binge Drinking's Effects on the Body. Alcohol Res 39:99-109
Molina, Patricia E; Simon, Liz; Amedee, Angela M et al. (2018) Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings. Alcohol Alcohol 53:439-447
Ford Jr, Stephen M; Simon Peter, Liz; Berner, Paul et al. (2018) Differential contribution of chronic binge alcohol and antiretroviral therapy to metabolic dysregulation in SIV-infected male macaques. Am J Physiol Endocrinol Metab :
Boule, Lisbeth A; Ju, Cynthia; Agudelo, Marisela et al. (2018) Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 66:35-43
Glick, Jennifer L; Andrinopoulos, Katherine M; Theall, Katherine P et al. (2018) ""Tiptoeing Around the System"": Alternative Healthcare Navigation Among Gender Minorities in New Orleans. Transgend Health 3:118-126
Glick, Jennifer L; Theall, Katherine; Andrinopoulos, Katherine et al. (2018) For data's sake: dilemmas in the measurement of gender minorities. Cult Health Sex :1-16
Theall, Katherine P; Felker-Kantor, Erica; Wallace, Maeve et al. (2018) Considering high alcohol and violence neighborhood context using daily diaries and GPS: A pilot study among people living with HIV. Drug Alcohol Depend 187:236-241
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2018) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses 34:178-184
Samuelson, Derrick R; Burnham, Ellen L; Maffei, Vincent J et al. (2018) The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol 314:L107-L117
Glick, Jennifer L; Theall, Katherine P; Andrinopoulos, Katherine M et al. (2018) The Role of Discrimination in Care Postponement Among Trans-Feminine Individuals in the U.S. National Transgender Discrimination Survey. LGBT Health 5:171-179

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