This Component is designed to provide a flexible means for developing and exploring new research activities or directions, and unique opportunities that can evolve into independently funded research projects. During Years 10-14, the Pilot Component funded 11 different projects;three projects (all new) will be funded in Year 15. Work conducted in these projects was instrumental in developing 4 successful federal research grants;several successful stimulus grant applications can also be traced directly or indirectly to pilot projects. One funded pilot has evolved into a new component (Grant) in this application. The Pilot Component has also been quite successful in attracting investigators new to alcohol research (Lattal, Kroenke, Low, Neve, Nagel, David and Allen). During Years 16-20, we propose to fund an average of 3 projects per year with an average budget of about $35K/project. The expected duration of these projects will be 1-3 years, with most lasting 1-2 years. The Center Scientific Director (Hitzemann) will manage this Component. Pilot Project applications will be solicited annually from local (primarily OHSU- and VAMC-based) investigators. Each proposal will be evaluated for scientific merit / innovation and for relatedness to the Center's overall goals by at least two members of the Center's Scientific Advisory Board, the Scientific Director, and the Center Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Three new Projects are proposed for Year 16;all of these (10A, B and C) will cover project years 15 and 16 (assuming that significant progress warrants second year continuation). Three new projects (10D, E and F) will begin in year 17 and are expected to extend through year 18. Because we will continue each year to solicit new applications, the projects that are eventually funded may differ from those described here. Project 10-A (S. Murphy, PI) will examine the relationships among prenatal alcohol exposure, sex and stroke. Project 10-B (E. Boudreau, PI) will map brain changes in alcohol withdrawal using optical microangiography developed by the Co-I (R. Wang). Project 10-C (L. Sherman, PI) will examine the effects of ethanol exposure on hyaluronan-mediated adult neurogenesis as a potential mechanism contributing to alcoholic cognitive dysfunction. All three of these PIs are investigators new to alcohol research. Project 10-D (D. Rossi, PI) examines cellular mechanisms of alcohol use and withdrawal. Project 10-E (S. Mitchell, PI) is a clinical project that will examine the effects of alcohol on impulsivity and risk-taking in binge drinkers. Project 10-F (J. Crabbe, PI) will focus on alcohol tolerance and the transition from initial binge to chronic drinking in mice. Pilot Projects selected for funding during Years 18-20 are expected to contribute to the study of the behavioral genomics of alcoholism and the mechanisms underlying neuroadaptation to ethanol.

Public Health Relevance

The pilot projects represent a survey of new directions in biomedical research, and bring methods new to the Center to bear on health consequences of alcohol use disorders. Alcoholism is one of the most prevalent and financially costly challenges to the US population.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
United States
Zip Code
Xu, Ting; Falchier, Arnaud; Sullivan, Elinor L et al. (2018) Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. Cell Rep 23:429-441
Iancu, Ovidiu D; Colville, Alexander; Walter, Nicole A R et al. (2018) On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. Addict Biol 23:196-205
Morales, Angelica M; Jones, Scott A; Ehlers, Alissa et al. (2018) Ventral striatal response during decision making involving risk and reward is associated with future binge drinking in adolescents. Neuropsychopharmacology 43:1884-1890
Gavin, David P; Hashimoto, Joel G; Lazar, Nathan H et al. (2018) Stable Histone Methylation Changes at Proteoglycan Network Genes Following Ethanol Exposure. Front Genet 9:346
Purohit, Kush; Parekh, Puja K; Kern, Joseph et al. (2018) Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice. Alcohol Clin Exp Res 42:879-888
Müller-Oehring, Eva M; Kwon, Dongjin; Nagel, Bonnie J et al. (2018) Influences of Age, Sex, and Moderate Alcohol Drinking on the Intrinsic Functional Architecture of Adolescent Brains. Cereb Cortex 28:1049-1063
Iancu, Ovidiu Dan; Colville, Alex M; Wilmot, Beth et al. (2018) Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs. Alcohol Clin Exp Res :
Kafkafi, Neri; Agassi, Joseph; Chesler, Elissa J et al. (2018) Reproducibility and replicability of rodent phenotyping in preclinical studies. Neurosci Biobehav Rev 87:218-232
Qiu, J; Wagner, E J; Rønnekleiv, O K et al. (2018) Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels. J Neuroendocrinol 30:
Allen, Daicia C; Ford, Matthew M; Grant, Kathleen A (2018) Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. Curr Top Behav Neurosci 39:95-111

Showing the most recent 10 out of 291 publications