This P60 application is the competing renewal application for the multi-site Multi-disciplinary Alcoholism Research Center (MARC). The broad focus of our research is the multi-level investigation (from lifetime diagnostic to real-time ecological) of the etiology and course of alcohol use disorders and associated comorbidity in community (rather than clinically ascertained) samples, with a particular focus on the period of young adulthood. The MARC is organized as: (1) an Administrative Core, which is responsible for coordinating MARC-based research projects with each other, and with our broader R01-supported portfolio of genetic, prospective high-risk and human experimental and ecological studies, (2) a Science Resource Core for support of (i) sample ascertainment and tracking, (ii) data-base management for our phenotypic, genotypic and environmental exposure data, and (iii) assessment coordination, (3) a Pilot Project core to facilitate the development of junior faculty as new investigators;(4) an Outreach Core, which extends our outreach through a new 2-week annual Alcohol Research Training Summer School, targeting undergraduates, to increase, nationally, the diversity of the pool of future alcoholism researchers;(5) four research projects. New Project 8 proposes 3 alcohol challenge experiments to characterize acute alcohol effects on executive cognitive functioning on the ascending versus descending limbs of the BAG curve. New Project 7 proposes a new wave of data collection for our OZ-ALC GWAS sample of N=3600, 50% with alcohol dependence history, derived from studies of the Australian Twin Panel, to update information about drinking patterns and ADD, and retrospective data about early childhood exposures (especially maltreatment). Project 6 extends our real-time Ecological Momentary Assessment study of the relationships between negative and positive affect, initiation of drinking episodes, and positive and negative reinforcement by alcohol, by focusing on a patient group characterized by severe affective dysregulation and impulsivity (Borderline Personality Disorder), who are known to have high risk of alcohol dependence. Project 5 adds a molecular epidemiology component to the prospective ABCHS cohort studies, R01-funded projects led by Anokhin, Bucholz, Chassin, Heath and Sher, to inform in prospective samples genetic associations, and GxE effects, identified in Project 7 and in other ongoing GWAS and gene-mapping studies.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-BB (90))
Program Officer
Parsian, Abbas
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2018) Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy. Dev Psychol 54:199-208
Werner, Kimberly B; Cunningham-Williams, Renee M; Sewell, Whitney et al. (2018) The Impact of Traumatic Experiences on Risky Sexual Behaviors in Black and White Young Adult Women. Womens Health Issues 28:421-429
Carpenter, Ryan W; Tragesser, Sarah L; Lane, Sean P et al. (2018) Momentary assessment of everyday physical pain in outpatients with borderline personality disorder. Personal Disord :
Bartholow, Bruce D; Fleming, Kimberly A; Wood, Phillip K et al. (2018) Alcohol effects on response inhibition: Variability across tasks and individuals. Exp Clin Psychopharmacol 26:251-267
Waldron, Mary; Watkins, Nicole K; Bucholz, Kathleen K et al. (2018) Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink. Alcohol Clin Exp Res 42:120-127
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2018) Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis 14:277-283
Von Gunten, Curtis D; Volpert-Esmond, Hannah I; Bartholow, Bruce D (2018) Temporal dynamics of reactive cognitive control as revealed by event-related brain potentials. Psychophysiology 55:
Hepp, Johanna; Lane, Sean P; Wycoff, Andrea M et al. (2018) Interpersonal stressors and negative affect in individuals with borderline personality disorder and community adults in daily life: A replication and extension. J Abnorm Psychol 127:183-189
Martins, Jorge S; Bartholow, Bruce D; Cooper, M Lynne et al. (2018) Associations between executive functioning, affect-regulation drinking motives, and alcohol use and problems. Psychol Addict Behav 32:16-28
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302

Showing the most recent 10 out of 229 publications