The Vanderbilt Diabetes Research and Training Center (DRTC), in its 33rd continuous year of operation as a NIH-sponsored Diabetes Center, and seeks to continue its efforts to facilitate the discovery, application, and translation of scientific knowledge to improve the care of patients with diabetes. The Vanderbilt DRTC is an interdisciplinary program involving 98 participating faculty distributed among 18 departments in two schools and four colleges at Vanderbilt and at neighboring Meharry Medical College. The DRTC consists of: 1) Administrative Component that coordinates the scientific, organizational, and outreach activities of the DRTC;2) Biomedical Research Component that recruits and selects DRTC-affiliated investigators and supervises the research cores that facilitate and enhance their research;3) Prevention/Control Core with a Clinical Outcomes and Behavioral Sciences Unit at Vanderbilt and a Community Outreach and Health Disparities Unit (funded by a supplement to the Vanderbilt DRTC for Meharry Medical College), that work cooperatively;4) Pilot and Feasibility Program that facilitates the development of new investigators into fully independent scientists and encourages scientists in other fields to enter the field of diabetes research;and 5) Enrichment, Training, and Outreach Program that fosters an environment conducive to collaborative, interdisciplinary research (seminar series, Diabetes Day, visiting scientists), and to training new diabetes scientists (DRTC oversees three NIH-funded diabetes-related training programs). NIH support for the DRTC is greatly amplified by: 1) Vanderbilt's sustained commitment to provide research space and additional financial resources;2) a diverse, comprehensive array of research core services at Vanderbilt, which allows NIH funds to target unique, diabetes-related research cores;3) opening of the Vanderbilt Eskind Diabetes Clinic, which provides a new venue for the clinical and translational research of the DRTC;4) collaborative efforts with other NIH-funded research centers at Vanderbilt such as the GCRC;and 5) a formal Meharry- Vanderbilt Alliance that encourages research on health disparities related to diabetes. The activities of the DRTC are evolving and dynamic;they include additions to its investigator base, expansion of DRTC research areas, expanded focus on clinical and translational research (participant in CTSA efforts at Vanderbilt), and realignment and evolution of core support to provide unique, indispensable core services. Because of the DRTC and the environment it creates, DRTC-affiliated investigators have made important scientific contributions in basic science, clinical research, and translational science related to diabetes. As encouraged by the RFA, the Vanderbilt DRTC is also serving as a regional and national resource for the diabetes research community by working cooperatively with other academic centers.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-N (J1))
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Creecy, Amy; Uppuganti, Sasidhar; Unal, Mustafa et al. (2018) Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone 110:204-214
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129
Coppola, Jennifer J; Disney, Anita A (2018) Most calbindin-immunoreactive neurons, but few calretinin-immunoreactive neurons, express the m1 acetylcholine receptor in the middle temporal visual area of the macaque monkey. Brain Behav 8:e01071
Zhu, Lin; Luu, Thao; Emfinger, Christopher H et al. (2018) CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet. Diabetes 67:2494-2506
Lu, Sichang; McGough, Madison A P; Shiels, Stefanie M et al. (2018) Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model. Biomaterials 179:29-45
Horwitz, Elad; Krogvold, Lars; Zhitomirsky, Sophia et al. (2018) ?-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes 67:2305-2318
Kook, Seunghyi; Qi, Aidong; Wang, Ping et al. (2018) Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol 58:566-574
Hull, P C; Buchowski, M; Canedo, J R et al. (2018) Childhood obesity prevention cluster randomized trial for Hispanic families: outcomes of the healthy families study. Pediatr Obes 13:686-696
Harris, Nicholas A; Isaac, Austin T; G√ľnther, Anne et al. (2018) Dorsal BNST ?2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38:8922-8942
Wang, Feng; Katagiri, Daisuke; Li, Ke et al. (2018) Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. Magn Reson Med 80:2655-2669

Showing the most recent 10 out of 1487 publications