The current proposal includes five basic research projects, four clinical research projects,, educational and community support projects, and the Laboratory Core. Clinical diagnosis is handled by the physicians within the Adult Sickle Cell Clinic (Drs. Haynes and Hunter) and Pediatric Sickle Cell Clinic (Drs. Yang, Little, Pace, Gremse) and laboratory diagnosis within the Community Projects Blood Screening Laboratory and the Laboratory Core A at USA. Counseling is provided by the Community Project. Dr. Steven R. Goodman serves as Director of the USA Comprehensive Sickle Cell Center is responsible for all operations with specific oversight of all research projects. Dr. Johnson Haynes serves as Associate Director of Clinical Programs with oversight of the clinical care of 600 children and adults with sickle cell disease who are cared for within USA Sickle Cell clinics and hospital wings. Ms. Rose Peterson is Associate Director for Community Programs.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-Q (S1))
Program Officer
Evans, Gregory
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Project End
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Budget End
Support Year
Fiscal Year
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Indirect Cost
University of South Alabama
Internal Medicine/Medicine
Schools of Medicine
United States
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Pace, B S; Qian, X; Ofori-Acquah, S F (2004) Selective inhibition of beta-globin RNA transcripts by antisense RNA molecules. Cell Mol Biol (Noisy-le-grand) 50:43-51
Haynes Jr, Johnson; Baliga, B Surendra; Obiako, Boniface et al. (2004) Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway. Blood 103:3945-50
Haynes Jr, Johnson; Obiako, Boniface (2002) Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. Am J Physiol Heart Circ Physiol 282:H122-30
Foley, Heather A; Ofori-Acquah, Solomon F; Yoshimura, Akihiko et al. (2002) Stat3 beta inhibits gamma-globin gene expression in erythroid cells. J Biol Chem 277:16211-9
Abraham, Ann; Bencsath, F Aladar; Shartava, Archil et al. (2002) Preparation of irreversibly sickled cell beta-actin from normal red blood cell beta-actin. Biochemistry 41:292-6
Yang, Y M; Pace, B (2001) Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms. Pediatr Pathol Mol Med 20:87-106
Kakhniashvili, D G; Goodman, S R (2001) Isolation of spectrin subunits by reverse-phase high-performance liquid chromatography. Protein Expr Purif 23:249-51
Sangerman, J; Kakhniashvili, D; Brown, A et al. (2001) Spectrin ubiquitination and oxidative stress: potential roles in blood and neurological disorders. Cell Mol Biol Lett 6:607-36
Cepeda, M L; Allen, F H; Cepeda, N J et al. (2000) Physical growth, sexual maturation, body image and sickle cell disease. J Natl Med Assoc 92:4-Oct
Xu, L; Ferry, A E; Monteiro, C et al. (2000) Beta globin gene inhibition by antisense RNA transcripts. Gene Ther 7:438-44

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