The current proposal includes five basic research projects, four clinical research projects,, educational and community support projects, and the Laboratory Core. Clinical diagnosis is handled by the physicians within the Adult Sickle Cell Clinic (Drs. Haynes and Hunter) and Pediatric Sickle Cell Clinic (Drs. Yang, Little, Pace, Gremse) and laboratory diagnosis within the Community Projects Blood Screening Laboratory and the Laboratory Core A at USA. Counseling is provided by the Community Project. Dr. Steven R. Goodman serves as Director of the USA Comprehensive Sickle Cell Center is responsible for all operations with specific oversight of all research projects. Dr. Johnson Haynes serves as Associate Director of Clinical Programs with oversight of the clinical care of 600 children and adults with sickle cell disease who are cared for within USA Sickle Cell clinics and hospital wings. Ms. Rose Peterson is Associate Director for Community Programs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL038639-15
Application #
6536905
Study Section
Special Emphasis Panel (ZHL1-CSR-Q (S1))
Program Officer
Evans, Gregory
Project Start
1988-04-01
Project End
2004-03-31
Budget Start
2002-04-15
Budget End
2004-03-31
Support Year
15
Fiscal Year
2002
Total Cost
$1,257,029
Indirect Cost
Name
University of South Alabama
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Pace, B S; Qian, X; Ofori-Acquah, S F (2004) Selective inhibition of beta-globin RNA transcripts by antisense RNA molecules. Cell Mol Biol (Noisy-le-grand) 50:43-51
Haynes Jr, Johnson; Baliga, B Surendra; Obiako, Boniface et al. (2004) Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway. Blood 103:3945-50
Haynes Jr, Johnson; Obiako, Boniface (2002) Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. Am J Physiol Heart Circ Physiol 282:H122-30
Foley, Heather A; Ofori-Acquah, Solomon F; Yoshimura, Akihiko et al. (2002) Stat3 beta inhibits gamma-globin gene expression in erythroid cells. J Biol Chem 277:16211-9
Abraham, Ann; Bencsath, F Aladar; Shartava, Archil et al. (2002) Preparation of irreversibly sickled cell beta-actin from normal red blood cell beta-actin. Biochemistry 41:292-6
Yang, Y M; Pace, B (2001) Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms. Pediatr Pathol Mol Med 20:87-106
Kakhniashvili, D G; Goodman, S R (2001) Isolation of spectrin subunits by reverse-phase high-performance liquid chromatography. Protein Expr Purif 23:249-51
Sangerman, J; Kakhniashvili, D; Brown, A et al. (2001) Spectrin ubiquitination and oxidative stress: potential roles in blood and neurological disorders. Cell Mol Biol Lett 6:607-36
Cepeda, M L; Allen, F H; Cepeda, N J et al. (2000) Physical growth, sexual maturation, body image and sickle cell disease. J Natl Med Assoc 92:4-Oct
Xu, L; Ferry, A E; Monteiro, C et al. (2000) Beta globin gene inhibition by antisense RNA transcripts. Gene Ther 7:438-44

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