This proposal is the Comprehensive Cancer Center Biostatistics Unit at the University of Alabama at Birmingham (UAB) to serve as the Data Coordinating Center (DCC) for the Comprehensive Sickle Cell Centers. It is anticipated that the Sickle Cell Centers will conduct collaborative clinical research studies including clinical trials and epidemiologic studies. Furthermore, the development of a common database across Centers would provide the basis for stimulating new research initiatives. The DCC will provide data management and statistical needs for specific aspects of the Sickle Cell Centers program sharing common clinical protocols, as well as for information related to health services utilization and health outcomes. The DCC will coordinate the clinical collaboration between the sickle Cell Centers and will serve as the primary unit to collect, manage, statistically analyze, and store clinical study data; to design and develop protocols; prepare forms and the Manual of Operations; train center staff in data collection procedures; maintain the study database; monitor clinical center performance; provide patient accrual reports; perform appropriate statistical analyses of study data; and participating in the preparation of study publications. The Biostatistics Unit has considerable experience in serving as the statistical coordinating center for multicenter clinical trials groups and in providing support for Comprehensive Cancer Center and Center for AIDS Research, with a Comprehensive Sickle Cell Center and Center for Health Promotion at UAB, expertise in the medical, genetic, epidemiologic, and behavioral areas will be available to the DCC on an ongoing basis.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Comprehensive Center (P60)
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University of Alabama Birmingham
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Coats, Mamie T; Benjamin, W H; Hollingshead, S K et al. (2005) Antibodies to the pneumococcal surface protein A, PspA, can be produced in splenectomized and can protect splenectomized mice from infection with Streptococcus pneumoniae. Vaccine 23:4257-62
Telfair, Joseph; Alexander, Leah R; Loosier, Penny S et al. (2004) Providers' perspectives and beliefs regarding transition to adult care for adolescents with sickle cell disease. J Health Care Poor Underserved 15:443-61
Briles, David E; Hollingshead, Susan K; Paton, James C et al. (2003) Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J Infect Dis 188:339-48
Liu, Enli; Jelinek, Jaroslav; Pastore, Yves D et al. (2003) Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin. Blood 101:3294-301
Aslan, Mutay; Ryan, Thomas M; Townes, Tim M et al. (2003) Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization. J Biol Chem 278:4194-204
Lim, Dong Gun; Sweeney, Scott; Bloodsworth, Allison et al. (2002) Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity. Proc Natl Acad Sci U S A 99:15941-6
Coles, Barbara; Bloodsworth, Allison; Eiserich, Jason P et al. (2002) Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP. J Biol Chem 277:5832-40
Coles, Barbara; Bloodsworth, Allison; Clark, Stephen R et al. (2002) Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. Circ Res 91:375-81
Robinson, D Ashley; Briles, David E; Crain, Marilyn J et al. (2002) Evolution and virulence of serogroup 6 pneumococci on a global scale. J Bacteriol 184:6367-75
O'Donnell, V B; Freeman, B A (2001) Interactions between nitric oxide and lipid oxidation pathways: implications for vascular disease. Circ Res 88:12-21

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