Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Development Center (PN2)
Project #
3PN2EY016546-03S1
Application #
7356570
Study Section
Special Emphasis Panel (ZEY1-VSN (11))
Program Officer
Fisher, Richard S
Project Start
2004-09-30
Project End
2010-09-29
Budget Start
2006-09-30
Budget End
2007-09-29
Support Year
3
Fiscal Year
2007
Total Cost
$30,700
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Rupp, Levi J; Schumann, Kathrin; Roybal, Kole T et al. (2017) CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep 7:737
Roybal, Kole T; Rupp, Levi J; Morsut, Leonardo et al. (2016) Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell 164:770-9
Gordley, Russell M; Bugaj, Lukasz J; Lim, Wendell A (2016) Modular engineering of cellular signaling proteins and networks. Curr Opin Struct Biol 39:106-114
Coyle, Scott M; Lim, Wendell A (2016) Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution. Elife 5:
Morsut, Leonardo; Roybal, Kole T; Xiong, Xin et al. (2016) Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell 164:780-91
Schmid, Eva M; Bakalar, Matthew H; Choudhuri, Kaushik et al. (2016) Size-dependent protein segregation at membrane interfaces. Nat Phys 12:704-711
Gordley, Russell M; Williams, Reid E; Bashor, Caleb J et al. (2016) Engineering dynamical control of cell fate switching using synthetic phospho-regulons. Proc Natl Acad Sci U S A 113:13528-13533
Mitchell, Amir; Wei, Ping; Lim, Wendell A (2015) Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science 350:1379-83
Wu, Chia-Yung; Roybal, Kole T; Puchner, Elias M et al. (2015) Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science 350:aab4077
Wu, Chia-Yung; Rupp, Levi J; Roybal, Kole T et al. (2015) Synthetic biology approaches to engineer T cells. Curr Opin Immunol 35:123-30

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