Abstract

Heart diseases remain the leading cause of death in the US and is an important focus area for the Healthy People 2020 initiative. The long term goal ofthis application is to determine the causes of aggregation of multiple biological, psychological and life-style related cardiovascular disease (CVD) risk factors in individuals and their covariation in populations. It is possible that genetic variation associated with central physiological mechanisms, lil

Public Health Relevance

Cardiovascular disease remains a leading cause of morbidity and mortality. Identification of novel genetic risk factors that may underlie the aggregation of multiple biological, psychological and lifestyle related CVD risk factors in individuals has tremendous potential to guide the development of comprehensive evaluation and treatment options.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Transition Award (R00)
Project #
5R00HL094767-05
Application #
8477236
Study Section
Special Emphasis Panel (NSS)
Program Officer
Papanicolaou, George
Project Start
2011-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$236,569
Indirect Cost
$80,418

  Institution

Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Halder, Indrani; Matthews, Karen A; Buysse, Daniel J et al. (2015) African Genetic Ancestry is Associated with Sleep Depth in Older African Americans. Sleep 38:1185-93
Halder, I; Champlin, J; Sheu, L et al. (2014) PPAR? gene polymorphisms modulate the association between physical activity and cardiometabolic risk. Nutr Metab Cardiovasc Dis 24:799-805
Halder, Indrani; Kip, Kevin E; Mulukutla, Suresh R et al. (2012) Biogeographic ancestry, self-identified race, and admixture-phenotype associations in the Heart SCORE Study. Am J Epidemiol 176:146-55