Role of the B-box-v-1 Restriction by TRIM5alpha proteins

Diaz-Griffero, Felipe

Abstract

The recently discovferecl rhesus monkey protein;TRIM5

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Mental Health (NIMH)
• Type: Research Transition Award (R00)
• Project #: 5R00MH086162-03
• Application #: 8034698
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Colosi, Deborah
• Project Start: 2010-03-01
• Project End: 2012-02-29
• Budget Start: 2011-03-01
• Budget End: 2012-02-29
• Support Year: 3
• Fiscal Year: 2011
• Total Cost: $246,510

Institution

• Name: Albert Einstein College of Medicine
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 110521739
• City: Bronx
• State: NY
• Country: United States
• Zip Code: 10461

Publications

Opp, Silvana; Fricke, Thomas; Shepard, Caitlin et al. (2017) The small-molecule 3G11 inhibits HIV-1 reverse transcription. Chem Biol Drug Des 89:608-618

Yudina, Zinaida; Roa, Amanda; Johnson, Rory et al. (2015) RING Dimerization Links Higher-Order Assembly of TRIM5? to Synthesis of K63-Linked Polyubiquitin. Cell Rep 12:788-97

Yang, Yang; Luban, Jeremy; Diaz-Griffero, Felipe (2014) The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating. Methods Mol Biol 1087:29-36

White, Tommy E; Brandariz-Nuñez, Alberto; Valle-Casuso, Jose Carlos et al. (2013) Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. Virology 436:81-90

Yang, Yang; Fricke, Thomas; Diaz-Griffero, Felipe (2013) Inhibition of reverse transcriptase activity increases stability of the HIV-1 core. J Virol 87:683-7

Brandariz-Nuñez, Alberto; Roa, Amanda; Valle-Casuso, Jose Carlos et al. (2013) Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5?. Virology 435:463-71

Di Nunzio, Francesca; Danckaert, Anne; Fricke, Thomas et al. (2012) Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS One 7:e46037

Roa, Amanda; Hayashi, Fumiaki; Yang, Yang et al. (2012) RING domain mutations uncouple TRIM5? restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating. J Virol 86:1717-27

Valle-Casuso, Jose Carlos; Di Nunzio, Francesca; Yang, Yang et al. (2012) TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core. J Virol 86:5931-6

Diaz-Griffero, Felipe; Gallo, Daniel E; Hope, Thomas J et al. (2011) Trafficking of some old world primate TRIM5? proteins through the nucleus. Retrovirology 8:38