Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA011115-07
Application #
6621118
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Russo, Denise A
Project Start
1996-09-30
Project End
2007-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
7
Fiscal Year
2003
Total Cost
$261,600
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Cao, Qi; Mak, Ki M; Lieber, Charles S (2007) Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells. J Hepatol 46:124-33
Cao, Qi; Mak, Ki M; Lieber, Charles S (2006) DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction. Liver Int 26:221-31
Lieber, C S (2005) Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years. Rocz Akad Med Bialymst 50:7-20
Cao, Qi; Mak, Ki M; Lieber, Charles S (2005) Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide. Am J Physiol Gastrointest Liver Physiol 289:G95-107
Lieber, Charles S; Leo, Maria A; Mak, Ki M et al. (2004) Model of nonalcoholic steatohepatitis. Am J Clin Nutr 79:502-9
Lieber, Charles S (2004) Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 34:9-19
Lieber, Charles S; Leo, Maria A; Mak, Ki M et al. (2004) Acarbose attenuates experimental non-alcoholic steatohepatitis. Biochem Biophys Res Commun 315:699-703
Cao, Qi; Mak, Ki M; Ren, Chaoling et al. (2004) Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways. J Biol Chem 279:4292-304
Lieber, Charles S; Leo, Maria A; Cao, Qi et al. (2003) Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J Clin Gastroenterol 37:336-9
Xu, Youqing; Leo, Maria A; Lieber, Charles S (2003) Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1. Biochem Biophys Res Commun 308:614-8

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