Hypnotic-dependent insomnia (HDI) refers to insomnia maintained by the chronic use of sleep medications (hypnotics) with associated tolerance and dependence. As disproportionately high users of hypnotics, older adults are most likely to develop HDI, and they are most vulnerable to the negative side-effects associated with chronic benzodiazepine use. The efficacy of psychological treatments for insomnia is well established, but there has been relatively little research on the use of these same treatments for people with insomnia who are also dependent on hypnotics. The planned study will treat 90 older adults diagnosed with HDI secondary to benzodiazepine use in a randomized experiment with three conditions: scheduled gradual hypnotic withdrawal supplemented by a placebo desensitization, and scheduled gradual hypnotic withdrawal only. Assessments at baseline, post-treatment/withdrawal, and 1-year follow-up will include monitoring of hypnotic consumption, self report and laboratory sleep evaluations, drug screens, and measures of psychological and global functioning. Side-effects during the drug withdrawal period will also be monitored by self-report. The study will attempt to determine if adding psychological treatments to gradual drug withdrawal will improve success of drug withdrawal, diminish withdrawal side-effects, improve sleep, or improve psychological and global functioning compared to gradual drug withdrawal alone in the management of HDI with older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG014738-04S1
Application #
6948438
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Monjan, Andrew A
Project Start
1999-02-20
Project End
2005-08-31
Budget Start
2004-09-30
Budget End
2005-08-31
Support Year
4
Fiscal Year
2004
Total Cost
$23,122
Indirect Cost
Name
University of Memphis
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
055688857
City
Memphis
State
TN
Country
United States
Zip Code
38152
Molzof, Hylton E; Emert, Sarah E; Tutek, Joshua et al. (2018) Intraindividual sleep variability and its association with insomnia identity and poor sleep. Sleep Med 52:58-66
Dillon, Haley R; Lichstein, Kenneth L; Dautovich, Natalie D et al. (2015) Variability in self-reported normal sleep across the adult age span. J Gerontol B Psychol Sci Soc Sci 70:46-56
Woosley, Julie A; Lichstein, Kenneth L; Taylor, Daniel J et al. (2014) Hopelessness mediates the relation between insomnia and suicidal ideation. J Clin Sleep Med 10:1223-30
Thomas, S Justin; Lichstein, Kenneth L; Taylor, Daniel J et al. (2014) Epidemiology of bedtime, arising time, and time in bed: analysis of age, gender, and ethnicity. Behav Sleep Med 12:169-82
Lichstein, Kenneth L; Nau, Sidney D; Wilson, Nancy M et al. (2013) Psychological treatment of hypnotic-dependent insomnia in a primarily older adult sample. Behav Res Ther 51:787-96
Woosley, Julie A; Lichstein, Kenneth L; Taylor, Daniel J et al. (2012) Predictors of perceived sleep quality among men and women with insomnia. Behav Sleep Med 10:191-201
Carney, Colleen E; Buysse, Daniel J; Ancoli-Israel, Sonia et al. (2012) The consensus sleep diary: standardizing prospective sleep self-monitoring. Sleep 35:287-302
Ustinov, Yuriy; Lichstein, Kenneth L; Wal, Gregory S Vander et al. (2010) Association between report of insomnia and daytime functioning. Sleep Med 11:65-8
McCrae, Christina S; Wilson, Nancy M; Lichstein, Kenneth L et al. (2008) Self-reported sleep, demographics, health, and daytime functioning in young old and old old community-dwelling seniors. Behav Sleep Med 6:106-26
Soeffing, James P; Lichstein, Kenneth L; Nau, Sidney D et al. (2008) Psychological treatment of insomnia in hypnotic-dependant older adults. Sleep Med 9:165-71

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