Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI016805-16
Application #
2060414
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1980-04-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Cha, Jeong-Heon; Chang, Mee Young; Richardson, James A et al. (2003) Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin. Mol Microbiol 49:235-40
Brooke, Joanna S; Cha, Jeong-Heon; Eidels, Leon (2002) Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor. BMC Cell Biol 3:2
Cha, Jeong-Heon; Brooke, Joanna S; Chang, Mee Young et al. (2002) Receptor-based antidote for diphtheria. Infect Immun 70:2344-50
Cha, J H; Brooke, J S; Ivey, K N et al. (2000) Cell surface monkey CD9 antigen is a coreceptor that increases diphtheria toxin sensitivity and diphtheria toxin receptor affinity. J Biol Chem 275:6901-7
Brooke, J S; Cha, J H (2000) Molecular characterization of key diphtheria toxin:receptor interactions. Biochem Biophys Res Commun 275:374-81
Cha, J H; Brooke, J S; Eidels, L (1999) Hamster diphtheria toxin receptor: a naturally occurring chimera of monkey and mouse HB-EGF precursors. Biochem Biophys Res Commun 254:325-9
Brooke, J S; Cha, J H; Eidels, L (1998) Diphtheria toxin:receptor interaction: association, dissociation, and effect of pH. Biochem Biophys Res Commun 248:297-302
Cha, J H; Brooke, J S; Eidels, L (1998) Toxin binding site of the diphtheria toxin receptor: loss and gain of diphtheria toxin binding of monkey and mouse heparin-binding, epidermal growth factor-like growth factor precursors by reciprocal site-directed mutagenesis. Mol Microbiol 29:1275-84
Hooper, K P; Eidels, L (1996) Glutamic acid 141 of the diphtheria toxin receptor (HB-EGF precursor) is critical for toxin binding and toxin sensitivity. Biochem Biophys Res Commun 220:675-80
Hooper, K P; Eidels, L (1995) Localization of a critical diphtheria toxin-binding domain to the C-terminus of the mature heparin-binding EGF-like growth factor region of the diphtheria toxin receptor. Biochem Biophys Res Commun 206:710-7

Showing the most recent 10 out of 23 publications