Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018797-14
Application #
2060789
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1982-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20817
Prantner, Daniel; Perkins, Darren J; Vogel, Stefanie N (2017) AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling. J Biol Chem 292:292-304
Prantner, Daniel; Shirey, Kari Ann; Lai, Wendy et al. (2017) The ?-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection. J Leukoc Biol 102:1103-1113
Perrin-Cocon, Laure; Aublin-Gex, Anne; Sestito, Stefania E et al. (2017) TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection. Sci Rep 7:40791
Perkins, Darren J; Vogel, Stefanie N (2016) Inflammation: Species-specific TLR signalling -- insight into human disease. Nat Rev Rheumatol 12:198-200
Keegan, Achsah D; Shirey, Kari Ann; Bagdure, Dayanand et al. (2016) Enhanced allergic responsiveness after early childhood infection with respiratory viruses: Are long-lived alternatively activated macrophages the missing link? Pathog Dis 74:
Perkins, Darren J; Rajaiah, Rajesh; Tennant, Sharon M et al. (2015) Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively. J Immunol 195:2461-71
Rajaiah, Rajesh; Perkins, Darren J; Ireland, Derek D C et al. (2015) CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance. Proc Natl Acad Sci U S A 112:8391-6
Piao, Wenji; Shirey, Kari Ann; Ru, Lisa W et al. (2015) A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza. Cell Rep 11:1941-52
Mistry, Pragnesh; Laird, Michelle H W; Schwarz, Ryan S et al. (2015) Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A 112:5455-60
Perkins, Darren J; Vogel, Stefanie N (2015) Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs). Cytokine 74:171-4

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