We propose to characterize the murine T-cell antigen receptor genes using recombinant DNA techniques and microchemical instrumentation. There are at least two families of T-cell receptor genes, Alpha and Beta. We have DNA probes for the Beta gene family that will allow us to study the structure, organization, rearrangements, diversification and evolution of these genes. We plan to study how these genes change during T-cell development. We also will attempt to clone DNA probes for the Alpha gene family and characterize these genes in a similar manner.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022274-05
Application #
3133199
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1985-04-01
Project End
1991-03-31
Budget Start
1989-04-01
Budget End
1991-03-31
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125