|
Doyle, Kelly; Fitzpatrick, F A (2010) Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function. J Biol Chem 285:17417-24
|
|
Covey, Tracy M; Edes, Kornelia; Coombs, Gary S et al. (2010) Alkylation of the tumor suppressor PTEN activates Akt and ýý-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One 5:e13545
|
|
Cassidy, Pamela B; Edes, Kornelia; Nelson, Chad C et al. (2006) Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles. Carcinogenesis 27:2538-49
|
|
Wagner, Tracy M; Mullally, James E; Fitzpatrick, F A (2006) Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translati J Biol Chem 281:2598-604
|
|
Moos, Philip J; Edes, Kornelia; Mullally, James E et al. (2004) Curcumin impairs tumor suppressor p53 function in colon cancer cells. Carcinogenesis 25:1611-7
|
|
Fitzpatrick, F A (2004) Cyclooxygenase enzymes: regulation and function. Curr Pharm Des 10:577-88
|
|
Yu, Margaret K; Moos, Philip J; Cassidy, Pamela et al. (2004) Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. J Biol Chem 279:28028-35
|
|
Verbitski, Sheryl M; Mullally, James E; Fitzpatrick, Frank A et al. (2004) Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity. J Med Chem 47:2062-70
|
|
Moos, Philip J; Edes, Kornelia; Cassidy, Pamela et al. (2003) Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase. J Biol Chem 278:745-50
|
|
Fitzpatrick, F A; Wheeler, Richard (2003) The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents. Int Immunopharmacol 3:1699-714
|
Showing the most recent 10 out of 29 publications
