Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI027175-08
Application #
2063734
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1989-01-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Maryland College Park
Department
Type
Organized Research Units
DUNS #
City
College Park
State
MD
Country
United States
Zip Code
20742
Chen, C C; Herzberg, O (2001) Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine. Biochemistry 40:2351-8
Chen, C C; Herzberg, O (1999) Relocation of the catalytic carboxylate group in class A beta-lactamase: the structure and function of the mutant enzyme Glu166-->Gln:Asn170-->Asp. Protein Eng 12:573-9
Banerjee, S; Pieper, U; Kapadia, G et al. (1998) Role of the omega-loop in the activity, substrate specificity, and structure of class A beta-lactamase. Biochemistry 37:3286-96
Pieper, U; Kapadia, G; Mevarech, M et al. (1998) Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii. Structure 6:75-88
Pieper, U; Hayakawa, K; Li, Z et al. (1997) Circularly permuted beta-lactamase from Staphylococcus aureus PC1. Biochemistry 36:8767-74
Banerjee, S; Shigematsu, N; Pannell, L K et al. (1997) Probing the non-proline cis peptide bond in beta-lactamase from Staphylococcus aureus PC1 by the replacement Asn136 --> Ala. Biochemistry 36:10857-66
Chen, C C; Smith, T J; Kapadia, G et al. (1996) Structure and kinetics of the beta-lactamase mutants S70A and K73H from Staphylococcus aureus PC1. Biochemistry 35:12251-8
Zawadzke, L E; Chen, C C; Banerjee, S et al. (1996) Elimination of the hydrolytic water molecule in a class A beta-lactamase mutant: crystal structure and kinetics. Biochemistry 35:16475-82
Liao, D I; Kapadia, G; Ahmed, H et al. (1994) Structure of S-lectin, a developmentally regulated vertebrate beta-galactoside-binding protein. Proc Natl Acad Sci U S A 91:1428-32
Chen, C C; Rahil, J; Pratt, R F et al. (1993) Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis. J Mol Biol 234:165-78

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