Abstract

The applicant proposes to examine the role of the vpr protein in the architecture of the HIV virion. He wishes to investigate the mechanism of its non-specific trans-activation of diverse promoter elements, and to determine its role in the life cycle of HIV. Based on preliminary results, the applicant believes that vpr may perform an essential function very early in the virus replication cycle in natural infections.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031354-04
Application #
3146334
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1991-07-01
Project End
1995-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Chen, S S; Ferrante, A A; Terwilliger, E F (1996) Characterization of an envelope mutant of HIV-1 that interferes with viral infectivity. Virology 226:260-8
Mayer, H B; Wanke, C A; Du, B et al. (1995) HIV-1 Tat modulates invasion by a bacterial enteric pathogen into a human intestinal cell line. AIDS 9:1237-42
Gabuzda, D H; Lawrence, K; Langhoff, E et al. (1992) Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. J Virol 66:6489-95