HIV-1 Protease Inhibitor-Resistant Mutants

Swanstrom, Ronald I.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI032892-05
• Application #: 2067778
• Study Section: AIDS and Related Research Study Section 3 (ARRC)
• Project Start: 1992-08-01
• Project End: 1998-05-31
• Budget Start: 1996-06-01
• Budget End: 1998-05-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: University of North Carolina Chapel Hill
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Swanstrom, R; Erona, J (2000) Human immunodeficiency virus type-1 protease inhibitors: therapeutic successes and failures, suppression and resistance. Pharmacol Ther 86:145-70

Pettit, S C; Sanchez, R; Smith, T et al. (1998) HIV type 1 protease inhibitors fail to inhibit HTLV-I Gag processing in infected cells. AIDS Res Hum Retroviruses 14:1007-14

Kaplan, A H; Manchester, M; Smith, T et al. (1996) Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication. J Virol 70:5840-4

Kaplan, A H; Michael, S F; Wehbie, R S et al. (1994) Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc Natl Acad Sci U S A 91:5597-601