Gonococci adhere to and enter certain cell types, aided by several surface proteins. They elaborate one or more toxins to compromise ciliary function and aid colonization. They encounter a variety of environmental conditions as they progress through the various stages of a mucosal infection, and are likely to adapt to these changes by turning various genes on or off. In the last several years, we have laid the groundwork for studying at the molecular level several aspects of GC/host interactions. We propose to continue these studies, which we believe will help us understand key elements of GC biology. A portion of these studies may also help us identify steps for the intervention of cytopathology in gonorrhea, and thereby help prevent a major cause of sterility in women.
| Brettin, Thomas; Altherr, Michael R; Du, Ying et al. (2005) Expression capable library for studies of Neisseria gonorrhoeae, version 1.0. BMC Microbiol 5:50 |
| Arvidson, C G; Powers, T; Walter, P et al. (1999) Neisseria gonorrhoeae PilA is an FtsY homolog. J Bacteriol 181:731-9 |
| Arvidson, C G; Kirkpatrick, R; Witkamp, M T et al. (1999) Neisseria gonorrhoeae mutants altered in toxicity to human fallopian tubes and molecular characterization of the genetic locus involved. Infect Immun 67:643-52 |
| Arvidson, C G; So, M (1997) Isolation and biochemical characterization of the PilA protein of Neisseria meningitidis. Arch Biochem Biophys 348:357-62 |
| Merz, A J; So, M (1997) Attachment of piliated, Opa- and Opc- gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins. Infect Immun 65:4341-9 |
