Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI037230-03
Application #
2073898
Study Section
Special Emphasis Panel (SRC (75))
Project Start
1994-09-30
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rhode Island
Department
Type
Organized Research Units
DUNS #
135531015
City
Kingston
State
RI
Country
United States
Zip Code
02881
Pichu, Sivakamasundari; Ribeiro, José M C; Mather, Thomas N et al. (2014) Purification of a serine protease and evidence for a protein C activator from the saliva of the tick, Ixodes scapularis. Toxicon 77:32-9
Pichu, Sivakamasundari; Yalcin, Emine B; Ribeiro, José Mc et al. (2011) Molecular characterization of novel sulfotransferases from the tick, Ixodes scapularis. BMC Biochem 12:32
Yalcin, Emine Bihter; Stangl, Hubert; Pichu, Sivakamasundari et al. (2011) Monoamine neurotransmitters as substrates for novel tick sulfotransferases, homology modeling, molecular docking, and enzyme kinetics. ACS Chem Biol 6:176-84
Karim, Shahid; Troiano, Emily; Mather, Thomas N (2010) Functional genomics tool: gene silencing in Ixodes scapularis eggs and nymphs by electroporated dsRNA. BMC Biotechnol 10:1
Pichu, Sivakamasundari; Ribeiro, José M C; Mather, Thomas N (2009) Purification and characterization of a novel salivary antimicrobial peptide from the tick, Ixodes scapularis. Biochem Biophys Res Commun 390:511-5
Kotsyfakis, Michalis; Anderson, Jennifer M; Andersen, John F et al. (2008) Cutting edge: Immunity against a ""silent"" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed. J Immunol 181:5209-12
Karim, Shahid; Kenny, Bronwyn; Troiano, Emily et al. (2008) RNAi-mediated gene silencing in tick synganglia: a proof of concept study. BMC Biotechnol 8:30
Sa-Nunes, Anderson; Bafica, Andre; Lucas, David A et al. (2007) Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis saliva. J Immunol 179:1497-505
Kotsyfakis, Michalis; Karim, Shahid; Andersen, John F et al. (2007) Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis. J Biol Chem 282:29256-63
Karim, Shahid; Miller, Nathan J; Valenzuela, Jesus et al. (2005) RNAi-mediated gene silencing to assess the role of synaptobrevin and cystatin in tick blood feeding. Biochem Biophys Res Commun 334:1336-42

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