Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI043455-01A1
Application #
2848299
Study Section
Virology Study Section (VR)
Program Officer
Meegan, James M
Project Start
1999-09-30
Project End
2004-08-31
Budget Start
1999-09-30
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Vande Burgt, Nathan H; Kaletsky, Rachel L; Bates, Paul (2015) Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism. Viruses 7:5587-602
Francica, Joseph R; Varela-Rohena, Angel; Medvec, Andrew et al. (2010) Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein. PLoS Pathog 6:e1001098
Francica, Joseph R; Matukonis, Meghan K; Bates, Paul (2009) Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein. Virology 383:237-47
Kaletsky, Rachel L; Francica, Joseph R; Agrawal-Gamse, Caroline et al. (2009) Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein. Proc Natl Acad Sci U S A 106:2886-91
Kaletsky, Rachel L; Simmons, Graham; Bates, Paul (2007) Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity. J Virol 81:13378-84
Simmons, Graham; Rennekamp, Andrew J; Bates, Paul (2006) Proteolysis of SARS-associated coronavirus spike glycoprotein. Adv Exp Med Biol 581:235-40
Amberg, Sean M; Netter, Robert C; Simmons, Graham et al. (2006) Expanded tropism and altered activation of a retroviral glycoprotein resistant to an entry inhibitor peptide. J Virol 80:353-9
Simmons, Graham; Gosalia, Dhaval N; Rennekamp, Andrew J et al. (2005) Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A 102:11876-81
Simmons, Graham; Reeves, Jacqueline D; Rennekamp, Andrew J et al. (2004) Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc Natl Acad Sci U S A 101:4240-5
Simmons, Graham; Rennekamp, Andrew J; Chai, Ning et al. (2003) Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection. J Virol 77:13433-8

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