Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI053724-02
Application #
6759250
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Program Officer
Rogers, Martin J
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$397,599
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Pompey, Justine M; Foda, Bardees; Singh, Upinder (2015) A Single RNaseIII Domain Protein from Entamoeba histolytica Has dsRNA Cleavage Activity and Can Help Mediate RNAi Gene Silencing in a Heterologous System. PLoS One 10:e0133740
Rastew, Elena; Morf, Laura; Singh, Upinder (2015) Entamoeba histolytica rhomboid protease 1 has a role in migration and motility as validated by two independent genetic approaches. Exp Parasitol 154:33-42
Foda, Bardees M; Singh, Upinder (2015) Dimethylated H3K27 Is a Repressive Epigenetic Histone Mark in the Protist Entamoeba histolytica and Is Significantly Enriched in Genes Silenced via the RNAi Pathway. J Biol Chem 290:21114-30
Pompey, Justine M; Morf, Laura; Singh, Upinder (2014) RNAi pathway genes are resistant to small RNA mediated gene silencing in the protozoan parasite Entamoeba histolytica. PLoS One 9:e106477
Pearson, Richard J; Morf, Laura; Singh, Upinder (2013) Regulation of H2O2 stress-responsive genes through a novel transcription factor in the protozoan pathogen Entamoeba histolytica. J Biol Chem 288:4462-74
Zhang, Hanbang; Ehrenkaufer, Gretchen M; Hall, Neil et al. (2013) Small RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes. BMC Genomics 14:53
Morf, Laura; Pearson, Richard J; Wang, Angelia S et al. (2013) Robust gene silencing mediated by antisense small RNAs in the pathogenic protist Entamoeba histolytica. Nucleic Acids Res 41:9424-37
Lin, Audrie; Bik, Elisabeth M; Costello, Elizabeth K et al. (2013) Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States. PLoS One 8:e53838
Vicente, João B; Tran, Vy; Pinto, Liliana et al. (2012) A detoxifying oxygen reductase in the anaerobic protozoan Entamoeba histolytica. Eukaryot Cell 11:1112-8
Rastew, Elena; Vicente, Joao B; Singh, Upinder (2012) Oxidative stress resistance genes contribute to the pathogenic potential of the anaerobic protozoan parasite, Entamoeba histolytica. Int J Parasitol 42:1007-15

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