Despite decades of research, the development of a successful HIV-1 vaccine has not yet been achieved. A better understanding of the functions of activated lymphocytes is therefore desired. The long-term objective of our research is to comprehend the full potentials of HIV-1-envelope-specific immune cells. CD4+ T-cells contribute to HIV-1 control by supporting antibody production by 8-cells and the activation/maintenance of CD8+ T-cells. However, based on our recent data, it appears that envelope-specific CD4+ T-cells may additionally contribute directly to the control of virus-infected cells, independent of 8-cell or CD8+ T-cell activity. The studies proposed here will determine how these CD4+ T-cells confer their 'protector' effect.
Specific Aim : To determine the phenotype, cytokine secretion capacities, and killer potentials of the HIV-1 envelope-specific CD4+ T-cells that protect against envelope-recombinant virus in the absence of 8-cell or CD8+ T-cell functions. Experiments are designed to fill fundamental gaps in our understanding of how virus is controlled by the immune system. Results from these experiments may be invaluable to the construction of new, successful HIV-1 vaccines designed to capture the full potentials of the immune response.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project (R01)
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AIDS Immunology and Pathogenesis Study Section (AIP)
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Pensiero, Michael N
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St. Jude Children's Research Hospital
United States
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Rudraraju, Rajeev; Jones, Bart G; Sealy, Robert et al. (2013) Respiratory syncytial virus: current progress in vaccine development. Viruses 5:577-94
Jones, B G; Hayden, R T; Hurwitz, J L (2013) Inhibition of primary clinical isolates of human parainfluenza virus by DAS181 in cell culture and in a cotton rat model. Antiviral Res 100:562-6
Jones, Bart G; Sealy, Robert E; Zhan, Xiaoyan et al. (2012) UV-inactivated vaccinia virus (VV) in a multi-envelope DNA-VV-protein (DVP) HIV-1 vaccine protects macaques from lethal challenge with heterologous SHIV. Vaccine 30:3188-95
Hurwitz, Julia L (2011) Respiratory syncytial virus vaccine development. Expert Rev Vaccines 10:1415-33
Surman, Sherri L; Rudraraju, Rajeev; Woodland, David L et al. (2011) Clonally related CD8+ T cells responsible for rapid population of both diffuse nasal-associated lymphoid tissue and lung after respiratory virus infection. J Immunol 187:835-41
Surman, Sherri L; Brown, Scott A; Jones, Bart G et al. (2010) Clearance of HIV type 1 envelope recombinant sendai virus depends on CD4+ T cells and interferon-gamma but not B cells, CD8+ T cells, or perforin. AIDS Res Hum Retroviruses 26:783-93
Brown, Scott A; Surman, Sherri L; Sealy, Robert et al. (2010) Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials. Viruses 2:435-467
Sealy, Robert; Jones, Bart G; Surman, Sherri L et al. (2009) Short communication: The dead cell: a potent escort for HIV type 1 transinfection. AIDS Res Hum Retroviruses 25:1123-8