A randomized, double-blind clinical trial has been designed that will test the efficacy and safety of fluoride therapy in the prevention of further vertebral compression fractures in white postmenopausal females (the segment of the population at greatest risk) who have already sustained at least one vertebral fracture as a result of osteoporosis. The trial will also determine prospectively the fracture incidence of the population at risk prior to the initiation of fluoride therapy. We shall attempt to determine those indices of skeletal homeostasis that might predict the long-term response to fluoride therapy either before therapy is initiated or within the first three to six months after starting therapy. The effect of fluoride therapy on the morbidity from vertebral compression fractures will also be determined. We shall directly compare four methods of detecting vertebral fractures (serial measurement of vertical height, clinical episodes of acute back pain, measurements of vertebral body dimensions on standard radiographs of the spine in the lateral projection, and bone scan) to determine which is the most sensitive, safe and cost effective method of accurately detecting new fractures. We shall obtain demographic data relating to the risk factors for the development of osteoporosis in patients who already have the disease, patients who specifically present for an evaluation of their risk of developing the disease, and from a control population. This data will include a measurement of peripheral bone mineral density. From the historical and densitometric data we shall develop an """"""""osteoporosis risk score"""""""" which will be suitable for prospective analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR028583-09
Application #
3155689
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1981-08-01
Project End
1990-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Henry Ford Health System
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Nelson, D A; Kleerekoper, M; Peterson, E L (1994) Reversal of vertebral deformities in osteoporosis: measurement error or ""rebound""? J Bone Miner Res 9:977-82
Nelson, D A; Kleerekoper, M; Peterson, E et al. (1993) Skin color and body size as risk factors for osteoporosis. Osteoporos Int 3:18-23
Kleerekoper, M; Nelson, D A; Peterson, E L et al. (1992) Outcome variables in osteoporosis trials. Bone 13 Suppl 1:S29-34
Kleerekoper, M; Peterson, E L; Nelson, D A et al. (1991) A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis. Osteoporos Int 1:155-61
Tilley, B C; Peterson, E L; Kleerekoper, M et al. (1990) Designing clinical trials of treatment for osteoporosis: recruitment and follow-up. Calcif Tissue Int 47:327-31