Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
3R01AR032961-08S1
Application #
3156461
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1991-02-08
Project End
1993-11-30
Budget Start
1991-02-08
Budget End
1991-11-30
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Guhathakurta, Piyali; Prochniewicz, Ewa; Grant, Benjamin D et al. (2018) High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin-myosin structure and function. J Biol Chem 293:12288-12298
Rohde, John A; Roopnarine, Osha; Thomas, David D et al. (2018) Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin. Proc Natl Acad Sci U S A 115:E7486-E7494
Muretta, Joseph M; Reddy, Babu J N; Scarabelli, Guido et al. (2018) A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function. Proc Natl Acad Sci U S A 115:E1779-E1788
Rohde, John A; Thomas, David D; Muretta, Joseph M (2017) Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke. Proc Natl Acad Sci U S A 114:E1796-E1804
Elam, W Austin; Cao, Wenxiang; Kang, Hyeran et al. (2017) Phosphomimetic S3D cofilin binds but only weakly severs actin filaments. J Biol Chem 292:19565-19579
Guhathakurta, Piyali; Prochniewicz, Ewa; Roopnarine, Osha et al. (2017) A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure. Biophys J 113:91-100
Colson, Brett A; Thompson, Andrew R; Espinoza-Fonseca, L Michel et al. (2016) Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics. Proc Natl Acad Sci U S A 113:3233-8
Avery, Adam W; Crain, Jonathan; Thomas, David D et al. (2016) A human ?-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding. Sci Rep 6:21375
Swanson, Carter J; Sommese, Ruth F; Petersen, Karl J et al. (2016) Calcium Stimulates Self-Assembly of Protein Kinase C ? In Vitro. PLoS One 11:e0162331
Espinoza-Fonseca, L Michel; Alamo, Lorenzo; Pinto, Antonio et al. (2015) Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition. Mol Biosyst 11:2167-79

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